放疗同步多西他赛方案与TP方案治疗中晚期宫颈癌疗效比较

目的探讨中晚期宫颈癌患者同步放化疗的化疗方案选择。方法选择120中晚期宫颈癌患者,完全随机分为对照组和观察组各60例。观察组接受放疗同步每周多西他赛方案,对照组接受放疗同步每周多西他赛+顺铂(TP)方案,观察两组的临床疗效及不良反应。结果观察组的临床有效率为98.3%,对照组的有效率为96.7%,组间差异无统计学意义(P>0.05)。观察组不良反应主要为消化道反应和骨髓抑制,对照组除消化道反应及骨髓抑制外,还出现肾损伤及过敏反应,其中对照组的消化道反应及肾损伤发生率显著高于观察组(P<0.05)。结论放疗同步每周多西他赛方案较TP方案不良反应小,疗效肯定,相对安全、合理,可在临床上进一步推广应用。

The clinical efficacy of Radiotherapy weekly docetaxel or TP concurrent chemoradiotherapy in advanced cervical cancer

Objective To investigate the clinical efficacy of Radiotherapy weekly docetaxel or TP concurrent chemoradiotherapy in advanced cervical cancer, to choose a better treatment. Methods 120 patients with advanced cervical cancer, completely randomly divided into a control group and the observation group, 60 cases in each. The observation group received Radiotherapy and weekly docetaxel programs and control group received radiotherapy synchronization weekly docetaxel ＋ cisplatin （TP） program, the clinical efficacy and adverse reactions of the two groups were observed. Results The clinical efficacy rate in observation group was 98.3%, which was not significantly higher than that in control group 96.7% ,the adverse were gastrointestinal toxicity and bone marrow suppression in the observation group, while control group existed kidney injury and allergic reactions in addition to gastrointestinal reactions and bone marrow suppression, including gastrointestinal reactions and renal injury incidence of the control group were significantly higher than that in the observation group （P〈0. 05） Conclusion Radiotherapy weekly docetaxel program has more slight adverse reactions and effective compared with the TP program, which is relatively safe, reasonable and can be further promote clini- cal application.