冠心病患者血尿酸水平与冠状动脉病变程度的相关性分析

目的:探讨血清UA水平与冠状动脉病变严重程度的关系。方法:回顾性分析2011年6月至2012年6月,在我科住院行冠状动脉造影检查者408例。根据造影结果,分为冠状动脉正常组和冠心病组,并根据SYNTAX评分,将冠心病组分为低危组(1～22分)、中危组(23～32分)及高危组(>33分)。测定空腹UA水平、空腹血脂:包括TC、TG、HDL-C及LDL-C。比较各组患者血脂、血UA水平。男性UA以<416μmol/L为正常值,女性以<357μmol/L为正常值,再将患者分为高UA组和正常UA组,比较两组SYNTAX评分,并进行相关性分析。结果:SYNTAX评分高危组、中危组与正常组比较TC、LDL-C显著增高,而正常组、低危组间差异无统计学意义(P>0.05)。SYNTAX评分高危组、中危组与同性别冠状动脉正常组比较,血UA水平显著增高。正常UA组与高UA血症组在年龄、性别、TC、TG、HDL-C及LDL-C的差异无统计学意义(P>0.05)。高UA血症组患者的冠状动脉SYNTAX评分显著高于正常血UA组。多元Logistic回归分析表明血UA水平与冠状动脉病变程度相关。结论:血UA是冠状动脉病变严重程度的相关危险因素,随着血UA水平的增高,冠状动脉病变程度增加。

Correlation between serum uric acid level and coronary lesion severity in coronary artery disease patients

Objective:To evaluate the correlation between serum uric acid level and coronary lesion severity in coronary artery disease(CAD)patients.Methods:A total of 408 patients receiving coronary angiographyfrom June 2011 to June 2012 were retrospectively analyzed.They were divided into two groups according to the results of coronary angiography.According to SYNTAX score,CAD patients were divided into three groups: low-risk group(1-22 score),middle-risk group(23-32 score) and high risk group(>33 score).Fasting serum uric acid levels,fasting blood lipids including total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C) were determined.Next,patients were divided into two groups according to the serum uric acid level for observing the relation ofthe serum uric acid lever and the SYNTAX score.Results: TC,LDL-C was significant higherin in SYNTAX scorehigh-risk group andmiddle-risk group compared with normal group.There is no statistically significant difference between the normal group and the low-risk group.Compared with normal coronary group of the same sex,uric acid levels in high-risk group andmiddle-risk group is significant higher.There is no statistically significant in age,sex,TC,TG,HDL-C,LDL-C between normal uric acid group and hyperuricemia group.The SYNTAX score is significantly higher in hyperuricemia group than in normal serum uric acid group.Multivariate logistic regression analysis indicated that serum uric acid is associated with coronary lesion severity.Conclusion:Serum uric acid is the risk factors of coronary lesion severity.With the increased uric acid level,the increase in the degree of coronary artery lesions,represent a greater cardiovascular risk.