曲马多与氯诺昔康用于腹腔镜胆囊切除超前镇痛对比研究

目的探讨曲马多与氯诺昔康超前镇痛对腹腔镜胆囊切除术(LC)后镇痛效果的影响。方法按入院先后顺序将120例ASAⅠ～Ⅱ级需行LC术患者随机均分为A、B、C 3组,每组40例。在气管插管前20min,A组预先静脉注射氯诺昔康8mg;B组预先静脉注射曲马多2.5mg/kg;C组预先静脉注射生理盐水5ml,作为对照组。观察术后各时点的视觉模拟评分(VAS)以及不良反应发生情况等。结果术后各时点的VAS评分:A、B两组均显著低于C组,组间比较差异有统计学意义(P<0.05);A、B两组之间比较差异无统计学意义(P>0.05)。消化道不良反应:B组明显高于A组,组间比较差异有统计学意义(P<0.05)。结论曲马多与氯诺昔康超前镇痛对LC术后镇痛效果确切,而氯诺昔康的消化道不良反应症状较少。

A Comparative Study of tramadol and lornoxicam for laparoscopic cholecystectomy preemptive analgesia

Objective To explore the impact of the application of the tramadol and lornoxicam preemptive analgesia analgesic after laparoscopic cholecystectomy （LC）. Methods According to the order of admission,120 cases ASAI- II lew el required for LC were randomly divided into three groups A, B, C group（n=40）. Before tracheal intubation 20min, A group is previously vein injection Lornoxicam 8 mg, group B is pre intravenous tramadol 2.5mg/kg, while C group is previously intravenous 5ml saline as a control group. Various situations are observed including visual analog scale （VAS） at postoperative each time point and the incidence of adverse reactions,and so on. Results Postoperative VAS scores for each time point.. A, B two groups were significantly lower than those in group C, the difference was statistically significant between groups （P〈0. 05）. The difference was not statistically significant between the two groups （A, B） （P〈0. 05）. Gastrointestinal adverse reactions.. Group B was significantly higher than that in group A, the difference between groups was statistically significant （P〈0. 05）. Conclusion Tramadol and lornoxicam preemptive analgesia analgesic effect of LC after very exact,whereas the Lornoxicam the gastrointestinal adverse reactions fewer symptoms.