| 慢性乙肝患者血浆内毒素水平与HBV DNA定量变化关系及其机制 |
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| 引用本文： | 王勤英,窦永青,赵龙凤. 慢性乙肝患者血浆内毒素水平与HBV DNA定量变化关系及其机制[J]. 山西医科大学学报, 2005, 36(3): 336-338 |
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| 作者姓名： | 王勤英 窦永青 赵龙凤 |
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| 作者单位： | 山西医科大学第一临床医学院感染病科,太原,030001 |
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| 基金项目： | 山西省卫生厅科研基金资助项目(200205) |
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| 摘 要： | 目的探讨慢性乙肝患者血浆内毒素(ET)水平与HBVDNA定量变化的关系及其机制。方法随机选取住院的慢性乙肝患者108例及HBV标志均为阴性的健康人15例,均严格无菌空腹采血,进行ET、T细胞亚群、HBVDNA定量等指标的检测。结果慢性乙肝患者随着血浆ET水平的升高,HBVDNA定量亦显著升高,P<0·01,但CD3、CD4、CD4/CD8均明显下降,P<0·05。结论慢性乙肝患者血浆ET水平升高,可致机体细胞免疫功能低下,从而使乙肝病毒持续复制,HBVDNA定量显著升高。
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| 关 键 词： | 慢性乙肝 内毒素类 DNA，肝炎病毒，乙型 |
| 文章编号： | 1007-6611(2005)03-0336-03 |
| 修稿时间： | 2005-03-10 |
Relationship between plasma endotoxemia and HBV DNA in patients with chronic B hepatitis |
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| WANG Qin-ying,DOU Yong-qing,ZHAO Long-feng. Relationship between plasma endotoxemia and HBV DNA in patients with chronic B hepatitis[J]. Journal of Shanxi Medical University, 2005, 36(3): 336-338 |
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| Authors: | WANG Qin-ying DOU Yong-qing ZHAO Long-feng |
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| Abstract: | Objective To study the relationship between plasma endotoxemia and HBV DNA in patients with chronic B hepatitis. Methods One hundred and eight patients with chronic B hepatitis(experiment group) and 15 healthy persons without HBV(control group) were chosen. The plasma was collected for measurement of endotoxin, peripheral blood T lymphocyte subset and HBV DNA in both groups before breakfast. Results There was a positive correlation between HBV DNA and plasma endotoxemia (P<0.01). At the same time, there was a negative correlation between HBV DNA and CD3,CD4 and CD4/CD8(P<0.05). Conclusion The increased plasma endotoxemia can decrease cellular immune, causing a continuous duplication of hepatitis B virus and high HBV DNA. |
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| Keywords: | hepatitis B chronic endotoxins DNA hepatitis B virus |
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