咪唑斯汀治疗慢性荨麻疹临床疗效评价及对血清IL-4水平的影响

目的：评价咪唑斯汀治疗慢性荨麻疹的疗效，探讨IL-4在慢性荨麻疹发病中的作用。方法：对32例慢性荨麻疹患用咪唑斯汀治疗，评价疗效，记录不良反应。同时用ELISA法检测慢性荨麻疹患治疗前后及正常人血清IL-4的水平。结果：治疗1、2wk后总有效率分别为62．5％、84．4％(P＜0．01)，不良反应3例。治疗前血清IL-4水平较正常人明显升高(P＜0．01)；治疗后IL-4水平下降(P＜0．01)，与正常人比较差异不甚明显(P＞0．05)。结论：咪唑斯汀是一种有效、安全的治疗慢性荨麻疹的药物，能降低慢性荨麻疹患血清IL-4的水平。

Efficacy of mizolastine in the treatment of patients with chronic urticaria and the change of serum IL-4

AIM: To evaluate the effect of mizolastine in patients with ch ronic urticaria and to explore the role of IL-4 in the process of chronic urtic aria. METHODS: 32 cases of chronic urticaria were treated with m izolastine, and the therapeutic effects and the side-effect were evaluated. The serum IL-4 levels were tested by ELISA. RESULTS: The total ef fective rates were 62.5 % and 84.4 % (P< 0.05 ) at the end of 1 wk and 2 wk, respectively. The side-effects were found in 3 cases ( 9 .4 %). The average levels of serum IL-4 before treatment were higher than tho se in controls (P< 0.01 ), but after treatment were not (P> 0.05 ), and before treatment were significantly higher than tho se after treatment (P< 0.01 ). CONCLUSIONS: M izolastine is an effective and safe drug in the treatment of patients with chron ic urticaria and the serum level of IL-4 decreases.