| 同型半胱氨酸对平滑肌细胞增殖的影响及机制 |
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| 引用本文： | 贾光宏,周云,余细球.同型半胱氨酸对平滑肌细胞增殖的影响及机制[J].中国心血管杂志,2000,5(1):13-14. |
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| 作者姓名： | 贾光宏 周云 余细球 |
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| 作者单位： | 湖北成宁医学院心内科,湖北，437100 |
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| 摘 要： | 目的 研究同型半胱氨酸(HCY)对平滑肌细胞增殖的影响及机制.方法利用~3H-TdR掺入、血小板衍化生长因子(PDGF)、血管紧张素Ⅱ(AugⅡ)生物活性检测,观察HCY对平滑肌细胞增殖、PDGF和AngⅡ的影响.结果HCY促进平滑肌细胞增殖,同时使平滑肌细胞分泌PDGF、AngⅡ增加,二者均有剂量效应关系.结论HCY促进血管平滑肌细胞增殖,可能是通过促使PDGF、AngⅡ分泌增加实现的.
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| 关 键 词： | 同型半胱氨酸 平滑肌细胞 增殖 |
The effects of homocysteine on the proliferation of smooth muscle cells and its mechanism |
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| Jia Cuanghong. Zhou Yun,Yu Xiqiou.The effects of homocysteine on the proliferation of smooth muscle cells and its mechanism[J].Chinese Journal of Cardiovascular Medicine,2000,5(1):13-14. |
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| Authors: | Jia Cuanghong Zhou Yun Yu Xiqiou |
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| Institution: | Jia Cuanghong. Zhou Yun,Yu Xiqiou. Department of Cardiology,Xian Ning medical college |
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| Abstract: | Objective To study the effect of homocysteine(HCY)on the proliferation of vessel smooth muscle cells (VSMC)and its mechanism. Methods By detecting PDGF、Ang Ⅱ activity and 3H]-TdR in corporation techniques, the effects of HCY on the proliferation of SMC and concentration of PDGF,Ang Ⅱ were observed. Resuits HCY induced the proliferation of VSMC and incresed SMC secreting PDGF、Ang Ⅱ There was a dose dependent relationship for both of them. Concluson HCY induced the proliferation of VSMC probably by increasing SMC secreting PDGF and Ang Ⅱ . |
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| Keywords: | Homecysteine Smooth muscle cell Proliferation |
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