微量元素与冠心病及其血脂的关系探讨

目的探讨微量元素与冠心病及其高血脂的关系.方法 用电感耦合等离子体原子发射光谱法测定了82例冠心病患者的6种微量元素变化,并与血脂做相关分析.结果示血清铁、锌、锌、铜比和铅在冠心病组较正常组明显增高,铬明显降低(P<0.01或0.001),铜和镉两组间无统计学差异.总胆固醇和低密度脂蛋白胆固醇分别与铁、锌、铅呈显著正相关,与铬呈显著负相关,高密度脂蛋白胆固醇与锌呈显著负相关(P<0.05或0.01).结论 提示部分微量元素的不平衡可能影响脂质代谢,并在冠心病中有重要发病学意义.

The Relationship Between Trace Elements With Coronary Heart Disease and Lipids

To explore the relationship between trace elements with coronary heart disease and lipids, inductively coupled plasma atomic emission spectroscopy (ICP-AES) was used to measure in 82 coronary heart disease cases the levels of 6 serum trace elements,which way analysed correlatively with blood lipids. The results showed that the concentrations of Fe,Zn Pb and the Zn/Cu ratio were higher while Cr was lower in the patients with coronary heart disease than that in the normal controls (P<0. 01 or 0. 001). But Cu and Cd were not significant difference between the two groups. Cholesterol and low-density lipoprotein cholesterol were positively correlated with serum Fe,Zn and Pb but negatively correlated with Cr. High-density lipoprotein cholesterol was negatively correlated with Zn. These results indicate that the unbalance of some trace elements may influence lipid metabolism, with an important role in the pathogenesis of the coronary heart disease.