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Bone Metastasis Revealing Hepatocellular Carcinoma: A Report of Three Cases with a Long Clinical Course
Authors:Jean-Luc Raoul,M.D.,,Thierry Le Simple,M.D.,,Elisabeth Le Prisé  ,M.D.,,Bernard Meunier,M.D.,,Mohammed Ben Hassel,M.D., Jean-Franç  ois Bretagne,M.D.
Affiliation:Service ďHepatogastroentémlogie, CHRU Pontchaillou 35033 Rennet Cédex., and Centre Régional de Lutte Contre le Cancer. "E Marquis" BP 6279 Rennes Cédex, France
Abstract:We report herein three cases of hepatoccllular carcinoma revealed by bone metastases. The metastases were located in the skull, the iliac bone, and the femur. The metastases were treated by radiotherapy, and/or surgery. With regard to the liver malignancy itself, two patients were treated by tamoxifen and one by chemo-embolizations. Two patients are alive 27 and 31 months after the first sign, and one died 31 months after the diagnosis. In conclusion, in patients with hepatocellular carcinoma revealed by bone metastases, long survival was obtainable in a few cases, and aggressive treatment could be of interest.
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