吸入NO对婴幼儿体外循环中细胞因子变化的影响及意义

目的 探讨吸入一氧化氮(NO)对婴幼儿体外循环手术中细胞因子变化的影响及意义.方法 室间隔缺损的婴幼儿30例随机分为对照组和NO组,NO组在体外循环期间吸人40×10-6NO直至关胸.在体外循环前、主动脉开放后1、3、5、10 min分别取右上肺静脉血和右心房血测定TNF-α、IL-8、IL-10.结果 NO组IL-10水平较对照组增高(P<0.01),TNF-α、IL-8则较对照组明显降低(P<0.05).结论 NO能抑制炎症性细胞因子,促进抗炎细胞因子的活性,故可减轻体外循环并发症.

The impact and significance of inhale nitric oxide on the changes of cytokine during cardiopulmonary bypass in infants

Objective To investigate the impact of inhahng nitric oxide (NO) on the changes of cytokine during cardiopulmo-nary bypass in infants. Methods Thirty infants with VSD were randomly divided into two groups: NO group and control group. Thepatients of NO group inhaled 40×10-6 NO during CPB. The change of TNF-α, I1-,-8, IL-10 were observed before CPB, at 1, 3, 5,10 min after aortic declamping. Results The values of TNF-α,IL-8 decreased significantly(P<0.05), and the values of IL-10 in-creased(P<0.01)in NO group. Conclusion iNO can inhibit the activation of inflammatory facts (TNF-α, IL-8 ),and promote theactivation of anti-inflammatory facts (IL-10). The use of NO may reduce the complication of CPB can be reduced by clinical means.