| 开普拓、5-氟尿嘧啶、亚叶酸钙时辰化疗治疗大肠癌肝转移的临床观察 |
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| 引用本文： | 侯冰宗,周少朋,房思炼,李霄凌,莫湘琼.开普拓、5-氟尿嘧啶、亚叶酸钙时辰化疗治疗大肠癌肝转移的临床观察[J].中华普通外科学文献（电子版）,2008,2(4):29-31. |
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| 作者姓名： | 侯冰宗 周少朋 房思炼 李霄凌 莫湘琼 |
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| 作者单位： | 中山大学附属第五医院胃肠外科,珠海,519000 |
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| 摘 要： | 目的观察开普拓、5-氟尿嘧啶、亚叶酸钙时辰化疗治疗大肠癌肝转移临床疗效及毒副作用。方法大肠癌手术后肝转移患者28例，随机分为A、B两组进行化疗，方案为：开普拓、5-氟尿嘧啶、亚叶酸钙，A组按时辰给药法治疗，B组按常规给药法治疗，按WHO标准观察两组患者的近期疗效及不良反应。结果衄有效率（CR＋PR）为78.5％，B组为35．7％，A组与B组相比较差异有显著性意义（P〈0．01），A组对化疗药物的毒副反应均较B组轻，A、B两组Ⅲ／Ⅳ度中性粒细胞减少、腹泻、脱发的发生率相比较差异均有显著性意义（P〈0．05）。结论开普拓、5-氟尿嘧啶、亚叶酸钙时辰化疗作为一种新的给药方式进行大肠癌肝转移化疗，具有较好的临床疗效及较低的毒副反应。
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| 关 键 词： | 开普拓 时辰化疗 大肠癌肝转移 |
Clinical study on chronomodulated chemotherapy of irinotecan combined with 5-FU and CF on colorectal carcinoma patients with hepatic metastasis |
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| HOU Bing-zong,ZHOU Shao-peng,FANG Si-lian,LI Xiao-ling,MO Xiang-qong.Clinical study on chronomodulated chemotherapy of irinotecan combined with 5-FU and CF on colorectal carcinoma patients with hepatic metastasis[J].Chinese Journal of General Surgery(Electronic Version),2008,2(4):29-31. |
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| Authors: | HOU Bing-zong ZHOU Shao-peng FANG Si-lian LI Xiao-ling MO Xiang-qong |
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| Institution: | HOU Bing-zong, ZH OU Shao-peng, FANG Si-lian, LI Xiao-ling, MO Xiang-qong. (The Fifth Affiliated Hospital of Sun Yat-Sen University,Zhuhai 519000 ,China) |
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| Abstract: | Objective To evaluate the clinical efficacy and the adverse drug reactions of chronomodulated chemotherapy of irinotecan(CPT-11) combined with 5-fluorouracil(5-FU) and calcium folinate(CF) on colorectal carcinoma patients with hepatic metastasis.Methods 28 colorectal carcinoma patients with hepatic metastasis were divided into group A and B.group A were employed the chronomodulated chemotherapy of CPT-11 combined with 5-FU and CF procedure,while group B used the CPT-11combined with 5-FU and CF rountinly.The... |
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| Keywords: | Irinotecan Chronomodulated chemotherapy Colorectal carcinoma with hepatic metastasis |
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