| 赤芍对家兔血管内膜平滑肌细胞增生的影响 |
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| 引用本文： | 朱慧民,金国健,林福禧. 赤芍对家兔血管内膜平滑肌细胞增生的影响[J]. 中国中医急症, 2005, 14(4): 349-350 |
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| 作者姓名： | 朱慧民 金国健 林福禧 |
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| 作者单位： | 浙江省台州市中心医院,台州,318000 |
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| 基金项目： | 浙江省台州市科技局资助项目，浙江省卫生厅资助项目 |
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| 摘 要： | 目的观察赤芍对兔颈动脉平滑肌细胞增殖细胞核抗原 (PCNA)表达作用,以了解赤芍对动脉损伤后内膜增生的影响.方法新西兰大白兔随机分为对照组、高脂饲料组、赤芍高剂量组及赤芍低剂量组,高脂喂养 8周后行兔颈总动脉球囊损伤术, 10周取材,用免疫组化法检测平滑肌细胞中 PCNA表达.结果各组内皮增生成分主要为平滑肌细胞.与高脂饲料组比较,赤芍高剂量组内膜、中膜、外膜 PCNA阳性着色及内膜增生面积均显著减少.结论赤芍有抑制平滑肌细胞增殖的作用.
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| 关 键 词： | 赤芍 增殖细胞核抗原 平滑肌细胞增生 |
| 文章编号： | 1004-745X(2005)04-0349-02 |
| 修稿时间： | 2004-07-05 |
The Preventive Effect of Radix Paeoniae Rubra on Proliferation in Rabbits'''' Vascular Smooth Muscle Cell |
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| Zhu Huimin,et al. The Preventive Effect of Radix Paeoniae Rubra on Proliferation in Rabbits'''' Vascular Smooth Muscle Cell[J]. Journal of Emergency in Traditional Chinese Medicine, 2005, 14(4): 349-350 |
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| Authors: | Zhu Huimin et al |
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| Abstract: | Objective:To obseve the preventive effect of Ra dix Paeoniae Rubra on proliferation in rabbits vascular smooth muscle cell.Methods:Rabbits were randomly divided into t he control group,the cholesterol grou p and the Radix Raeoniae Rubra group o f high -,low -dose.Balloon injury was performed in atherosclarotic rabbits indu ced by high cholesterol diet.The target segmen ts were harvested to perform immunoh istochemical study of proliferating cell nuclear antigen(PCNA).Results:The hyperplastic cell in in-tima was vascular smooth muscle cell.The areas of hyperplastic intima in the Radix Paeoniae Rubra group of high -dose we re significantly lower than that of t he cholesterol group with the positive expression o f PCNA being remarkably decreased.Conclusions:Radix Paeoniae Rubra has significan t preventive effect on Proliferatio n of vascular smooth muscle cell in rabbits. |
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| Keywords: | Radix Raeoniae Rubra proliferatin g cell nuclaer antigen prolifaration of vascular smooth muscle cell |
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