| 异种胰岛和胸腺联合移植治疗糖尿病的实验研究 |
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| 引用本文： | 申哲洙,吴后男,张学春,王有德. 异种胰岛和胸腺联合移植治疗糖尿病的实验研究[J]. 吉林大学学报(医学版), 2001, 27(5): 513-515 |
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| 作者姓名： | 申哲洙 吴后男 张学春 王有德 |
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| 作者单位： | 1. 吉林大学第一医院普外科
2. 吉林大学基础医学院病理解剖学教研室 |
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| 摘 要： | 目的 :探讨供者胸腺与胰岛联合移植在诱导免疫耐受中的作用。方法 :昆明种小鼠为供体 ,Wistar大鼠为受体。 A组为单纯胰岛移植组 ,B组为胰岛和胸腺联合移植组 ,C组为胸腺细胞预注射于受体胸腺 7d后 ,胰岛和胸腺联合移植组。结果 :A组移植物功能存活时间为 (6 .4 0± 1.90 ) d,B组为(2 1.2 0± 10 .74 ) d,C组为 (36 .70± 15 .11) d。 B组和 C组与 A组比较 ,差异具有显著性 (P<0 .0 5 )。结论 :胸腺移植对诱导免疫耐受、提高异种胰岛移植物存活有一定作用。
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| 关 键 词： | 异种胰岛/胸腺 移植 糖尿病 免疫耐受 |
| 文章编号： | 0253-3707(2001)05-0513-03 |
| 修稿时间： | 2000-05-09 |
Combined islet and thymus xenotransplantation therapy in experimental diabetic rats |
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| SHEN Zhe Zhu ,WU Hou nan ,ZHENG Xue chun ,WANG You de. Combined islet and thymus xenotransplantation therapy in experimental diabetic rats[J]. Journal of Jilin University: Med Ed, 2001, 27(5): 513-515 |
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| Authors: | SHEN Zhe Zhu WU Hou nan ZHENG Xue chun WANG You de |
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| Affiliation: | SHEN Zhe Zhu 1,WU Hou nan 2,ZHENG Xue chun 1,WANG You de 1 |
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| Abstract: | Objective:To study the effect of combined islet and thymus xenotransplantation in tolerance induction.Methods:Kunming mice were used as donors and Wistar rats as recipints.Group A received islet xenotransplantation only.Combined islet and thymus xenotransplantation were performed in Group B.Donor thymus cells were injected into recipient thymus 7 days before combined islet and thymus xenotransplantation were performed in Group C.Results:The mean graft survial time was (6 40±1 90) days in Group A,(21 20±10 74) days in Group B and (36 70±15 11) days in Group C respectively.There were significant difference between Group B,C and A( P <0 05).Concluson:Thymus transplantation is effective to induce xenograft tolerance and improve the functional survival time of islet xenograft. |
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| Keywords: | islet xenotrasplantation thymus transplantation diabetes mellitus immunotolerance |
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