胰岛素、瘦素、雄激素与多囊卵巢综合征发病机制研究进展

 多囊卵巢综合征（polycystic ovary syndrome，PCOS）是一种发病呈多因性、临床表现呈多态性的内分泌紊乱综合征。其发病机制至今尚未阐明，既往研究认为高胰岛素血症与高雄激素血症在PCOS发病机制中发挥着重要作用。近年来，又有报道高瘦素血症是PCOS发生不可忽略的因素。为此，本文综合分析了三者间的相互作用，并在此角度上探讨其与PCOS发病机制的相关性。

Research progress of polycystic ovary syndrome with insulin, leptin and androgen

Polycystic ovary syndrome (PCOS) is an endocrine disorder with a variety of etiopathogensis and clinic manifestations. Hitherto its pathogenesy is still uncleared. However, there have been increasing supports for the contribution of the hyperinsulinism and hyperandrogenaemia in the pathological process of the PCOS. Recent years, some literatures reported that hyperleptinaemia is also an important factor. This review seeks to bring together the pothogenesy of the PCOS with these factors.