成纤维细胞活化蛋白在乳腺癌组织的表达特征及临床意义

目的:观察基质成纤维细胞活化蛋白(fibroblast activation protein,FAP)在乳腺癌组织的分布特点、表达特征及其变化规律,探讨FAP在乳腺癌发生发展过程中的作用。方法:对术后病理证实为乳腺癌组织的82例病例进行回顾性分析,应用免疫组织化学法检测FAP的表达,探讨FAP在各临床病理参数组的表达分布特征。结果:免疫组化分析显示乳腺癌肿瘤细胞无FAP表达,FAP主要表达于肿瘤细胞周围基质成纤维细胞内。FAP表达与乳腺癌临床分期呈显著正相关(r=0.922,P=0.000)。非浸润性乳腺癌与浸润性乳腺癌FAP表达具有显著统计学差异(t=17.085P=0.000)。有淋巴结转移组较无淋巴结转移组FAP表达量高(t=11.003,P<0.01)。结论:FAP特异性表达于乳腺癌瘤周基质成纤维细胞,FAP在女性乳腺癌发生、发展、侵袭转移方面起到了重要的作用。

Expression and clinical significance of fibroblast activation protein in human breast cancer

Objective:To detect expression and significance of fibroblast activation protein(FAP) in the genesis,development and metastasis of female breast cancer.Methods:Total of 82 female breast cancer tissues proved by operation and pathology were analyzed retrospectively.The expression of FAP was detected by immunohistochemistry.The expression of FAP in various clinicopathologic groups was analyzed.Results:FAP was detected in stromal fibroblast cells around the tumor cells but not in tumor cells.The expression of FAP had a significant positive correlation with clinical stage(r=0.922,P=0.000).FAP between I(noninfiltrating carcinoma)and II(Invasive carcinoma)showed significant statistical difference(t=17.085 P=0.000).The expression of FAP in the group with lymph nodes’ metastasis was higher than the group without lymph nodes’ metastasis(t=11.003,P<0.01).Conclusion:FAP expresses in tumor stromal fibroblast cells.FAP plays an important role in the genesis,development and metastasis of female breast cancer.