阑尾类癌临床病理分析(附6例)

目的:探讨阑尾类癌的临床病理学特点。方法:收集6例阑尾类癌临床资料,结合免疫组化方法进行研究。结果:男性4例,女性2例,发病年龄14-57岁,平均33.60岁。发生部位近端2例,中段2例,末端2例。典型类癌3例,杯状细胞类癌1例,管状类癌1例,混合性类癌-腺癌1例。神经内分泌标记物Syn、CgA、NSE癌细胞均有不同程度表达。其中3例做了右半结肠切除术并化疗,随访10-36个月,均健在。结论:阑尾类癌组织形态特殊,诊断主要依靠组织病理学与免疫组化标记结果确定。早期发现、早期诊断与手术治疗,是提高患者生存期和治愈率的关键。

Carcinoid of the appendix: a clinicopathological analysis of 6 cases

Objective:To investigate the clinicopathologic characteristics of the appendiceal carcinoid.Methods: Clinicopathological analysis of 6 cases of appendiceal carcinoid was performed with immunohistochemical study.Resutls:The appendiceal carcinoid patients consisted of 4 males and 2 females,with the onset age ranging 14-57 years(median,33.6 years);2 cases of proximal appendix,2 of middle appendix,2 of terminal appendix;3 cases of typical carcinoid,1 case of goblet-cell carcinoid,1 case of tubular carcinoid,1 case of mixed carcinoid-adenocarcinoma,neuroendocrine markers Syn,CgA,NSE expressed in tumor cells.The right-side colonectomy and chemotherapy carried out in 3 patients,who were followed up 10-36 months,still survived.Conculsion: The histomorphology of appendiceal carcinoid is very special,can be diagnosed according to histopathology and immunohistochemistry results.The key to improve its survival and cure rates is early detection and operation.