大肠癌组织中Survivin和p73的表达及其意义

目的:探讨大肠癌组织中Survivin和p73的表达特点及其相互关系。方法:运用S-P免疫组织化学法染色结合图像分析,探讨Survivin和p73在大肠癌组织、癌旁组织及正常组织中的表达特点。结果:在60例大肠癌的癌、癌旁、正常组织标本中,Survivin表达的平均光密度值分别为:0.5443±0.0385、0.3263±0.0284、0.1467±0.0227;癌组织中Survivin的表达水平显著升高,与癌旁组织、正常组织中的表达比较存在显著差异(P<0.01)。p73表达的平均光密度值分别为:0.7617±0.0251、0.5327±0.0318、0.3460±0.0223;癌组织中p73蛋白的表达水平显著升高,与癌旁组织、正常组织中的表达比较存在显著差异(P<0.01)Survivin和p73在大肠癌组织中的表达存在依从关系(P<0.01),二者呈直线相关,相关系数为0.783。结论:Survivin和p73在大肠癌组织中高表达,与癌旁、正常组织中的表达比较有显著性差异,提示二者在大肠癌的发生发展中起一定的作用,是细胞恶变的指标;Survivin和p73在大肠癌的发生发展中具有协同作用,检测大肠癌患者Survivin和p73对控制大肠癌进展具有重要临床意义。

The expression and significance of Survivin and p73 in human colorectal carcinoma

Objective:To investigate the expression and significance of Survivin and p73 in human colorectal carcinoma.Methods:S-P immunohistochemical techniques and image analysis were used to detect the expression of Survivin and p73 in tumor tissue,para-tumor tissue and normal mucos of human colorectal caucinoma.Results:In 60 patients,the average values of light density of Survivin in tumor para-tumor and normal tissus were 0.5443±0.0385,0.3263±0.0284,0.1467±0.0227 and p73 were 0.7617±0.0251,0.5327±0.0318,0.3460±0.0223 respectively.A high expression of Survivin and p73 was discovered in tumor tissue(P<0.01) in tumor tissue,para-tumor tissue and normal mucosa of human colorectal carcinoma.The expression of Survivin and p73 had a linear correlation and the correlation coefficient was 0.783.There was a positive correlation between the expression of Survivin and p73 in human colorectal carcinoma.Conclusion:Survivin and p73 might play an important role in the development of human colorectal carcinoma,and Survivin and p73 had a coordinated effect in the course of development of human colorectal carcinoma.