Low-dose versus high-dose oxytocin augmentation of labor — A randomized trial |
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Authors: | Elly M. -J. Xenakis MD Oded Langer MD Jeanna M. Piper MD Deborah Conway MD Michael D. Berkus MD |
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Affiliation: | Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, Texas, USA |
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Abstract: | OBJECTIVE: Our purpose was to compare the efficacy and safety of low-dose versus high-dose oxytocin regimens in the augmentation of labor.STUDY DESIGN: Three hundred ten term pregnancies requiring augmentation of labor underwent randomization to receive either a low-dose or high-dose oxytocin augmentation regimen. Maternal demographics, labor-delivery data, and neonatal outcome were compared.RESULTS: The hgih-dose oxytocin group had a significant lower cesarean section rate, regarless of parity (10.4% vs 25.7%. p < 0.001), with no differences in maternal complications and neonatal outcomes. The time needed to correct the labor abnormality as also significantly decreased (1.24 ± 1.4 hours vs 3.12 ± 1.6 hours, p < 0.001) in the high-dose group.CONCLUSIONS: The use of a high-dose oxytocin regimen benefits both nulliparous and multiparous women requiring labor augmentation by significantly lowering both the time necessary to correct the labor normality and the need for cesarean section. |
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Keywords: | Labor abnormalities oxytoxin augmentation |
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