| 康脑液预处理对脑缺血再灌注损伤大鼠脑组织的谷氨酸/氨基丁酸比值的影响 |
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| 引用本文： | 石会娟,邹玉安,薛茜. 康脑液预处理对脑缺血再灌注损伤大鼠脑组织的谷氨酸/氨基丁酸比值的影响[J]. 中国临床药理学杂志, 2011, 27(6) |
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| 作者姓名： | 石会娟 邹玉安 薛茜 |
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| 作者单位： | 1. 河北北方学院,河北,张家口,075000
2. 河北北方学院,附属第一医院神经内科,河北张家口,075000 |
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| 基金项目： | 河北省卫生厅课题基金资助项目 |
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| 摘 要： | 目的 观察康脑液对局灶性脑缺血再灌注损伤大鼠脑组织中氨基酸类神经递质的的影响.方法 将60只大鼠随机分为6组:假手术组,模型组,康脑液低、中、高剂量组,依达拉奉组.用栓线法复制大鼠大脑中动脉栓塞模型,缺血2h再灌注1h后,断头取脑,用2,4-二硝基氟苯柱前衍生法,测定大鼠脑组织中Glu与γ-GABA含量.结果 与假手术组相比,模型组大鼠脑组织中Glu和γ -GABA含量均明显上升,Glu/GABA明显升高(P＜0.05);与模型组比较,康脑液能够不同程度地降低大鼠脑组织中Glu含量,降低γ-GABA含量,使Glu/GABA趋于正常,具有显著性差异(P＜0.05).结论 康脑液可能通过降低缺血再灌注损伤大鼠脑组织中Glu含量及Glu/GABA比值从而发挥脑保护作用.
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| 关 键 词： | 康脑液 脑缺血再灌注 高效液相色谱法 |
Effect of Kangnaoye on the ratio of Glu/GABA in rats during cerebral ischemia-reperfusion |
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| SHI Hui-juan,ZOU Yu-an,XUE Qian. Effect of Kangnaoye on the ratio of Glu/GABA in rats during cerebral ischemia-reperfusion[J]. The Chinese Journal of Clinical Pharmacology, 2011, 27(6) |
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| Authors: | SHI Hui-juan ZOU Yu-an XUE Qian |
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| Affiliation: | SHI Hui-juan1,ZOU Yu-an2,XUE Qian2 (1.Hebei North University,Zhangjiakou 075000,Hebei Province,China,2.Department of Neurology,The First Affiliated Hospital of Hebei North University,China) |
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| Abstract: | Objective To observe the effect of Kangnaoye on the amino acids neurotransmitter contents of brain in rats during cerebral ischemia-reperfusion in order to investigate the mechanism of action of Kangnaoye.Methods Sixty rats were randomly divided into 6 groups,such us sham-operation group,ischemia-reperfusion group,Kangnaoye groups with different dose,edaravone group.The models of cerebral ischemia-reperfusion were established in rats by methods of middle cerebral artery occlusion(MCAO).The animals were kill... |
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| Keywords: | Kangnaoye cerebral ischemia-reperfusion HPLC |
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