Mohnarin 2009年度报告:肠杆菌科细菌耐药监测

目的 了解2009年度我国临床分离肠杆菌科细菌对临床常用抗菌药物的耐药性.方法 卫生部全国细菌耐药监测网(Mohnarin)成员单位,按照监测方案要求,收集临床肠杆菌科细菌,并进行药物敏感性测试;依照美国实验室与标准化研究所(CLSI)2009标准,判断敏感性;用Whonet 5.5软件处理数据.结果 全国六大地区的114家医院参加监测,共收集肠杆菌科细菌74412株.其中,大肠埃希菌分离量居第1,为33844株,占45%;其次为肺炎克雷伯菌,为22071株(30%);再次为阴沟肠杆菌,为7310株(10%).敏感性最高的抗菌药物为碳青霉烯类,除阴沟肠杆菌对美罗培南和弗劳地枸橼酸杆菌对亚胺培南的耐药率在5%以上外;其他肠杆菌科细菌,对碳青霉烯类抗生素的耐药率都在3%左右或以下.大肠埃希菌、克雷伯杆菌属细菌和奇异变形杆菌ESBLs产生株的分离率分别为65.51%,40%以上和26.69%.碳青霉烯类抗生素对大肠埃希菌、克雷伯杆菌属细菌和奇异变形杆菌的ESBLs产生株和非产生株有良好的抗菌活性;酶抑制剂复方制剂对大肠埃希菌ESBLs产生株和非产生株都有良好的抗菌活性.ESBLs产生株对于其他各类抗菌药物的耐药率都显著高于非产生株.结论 肠杆菌科细菌对各类抗菌药物呈现不同程度耐药,有些具多重耐药特点;碳青霉烯类仍是肠杆菌科细菌最敏感的药物,但已出现碳青霉烯耐药菌,应引起重视.

Mohnarin 2009 report:surveillance of antimicrobial resistance in Enterobacteriaceae in China

Objective To investigate the antimicrobial resistance of Enterobacteriaceae in China in 2009.Methods All the clinical isolates of Enterobacteriaceae were collected and the susceptibility tests of the isolates were performed by 114 hospitals around China from 1st Jan.2009 to 31st Dec.2009.The susceptibilities of isolates to antimicrobial agents were determined by using CLSI(2009) guideline and the susceptibility data were processed with Whonet 5.5 software.Results In 2009,a total of 74412 Enterobacteriaceae ...