70岁以上老年肺癌手术并发症及相关因素分析

目的 探讨70岁以上老年肺癌病人手术治疗特点及影响术后并发症发生的危险因素.方法 回顾总结222例年龄≥70岁接受肺切除手术的老年肺癌病人临床资料.将术后出现严重并发症的病人纳入Ⅰ组,仅出现一般并发症的病人则纳入Ⅱ组,无并发症发生的病人纳入Ⅲ组.定义A1组=Ⅰ组+Ⅱ组,B1组=Ⅲ组,A2组=Ⅰ组、B2组=Ⅱ组+Ⅲ组.对可能影响术后并发症发生的危险因素分别在A1组与B1组间、A2组与B2组间进行单因素分析和二项logistic多因素回归分析.结果 术前161例病人合并其他疾病(72.5%).手术方式以单肺叶切除为主(64.9%),中位淋巴结清扫数为14个(0～57个).术后并发症总发生率63.5%,严重并发症发生率13.5%,围手术期死亡1.8%(4例).Logistic回归分析结果显示,影响术后总体并发症发生的独立危险因素为术前体重下降(P=0.020)、ASA分级(P＜0.001)、MVV(%预测值)(P=0.020)和淋巴结清扫数(P=0.004);影响术后严重并发症发生的独立危险因素为ASA分级(P=0.003)、MVV(%预测值)(P=0.018)和肿瘤位置(P=0.007).结论 重视术前体重下降及术中淋巴结清扫对70岁以上老年肺癌病人手术安全性的影响;对术前高ASA分级、低MVV(%预测值)水平以及肿瘤为中心型的70岁以上老年肺癌病人应特别加强围手术期管理以降低手术风险.

Abstract：

Objective This study is to analyse the clinical feature and risk factors of morbidity after pulmonary resection for lung cancer in patients older than 70 years. Methods The clinical records of 222 patients older than 70 years who had undergone pulmonary resection for their lung cancer was reviewed. The patients were divided into 3 groups: group Ⅰ including the patients who had severe postoperative complications, group Ⅱ including the patients who had mild complications and group Ⅲ including the patients who had no complications. Moreover, the definitions were made that group A1 = group Ⅰ+ Ⅱ , group B1 = group Ⅲ, group A2 = group Ⅰ and group B2 = group Ⅱ + Ⅲ. Univariate analyses and multivariate binary logistic regressions relating postoperative morbidity to risk factors were performed between the group Al and Bl, A2 and B2, resulting in the identification of the independent risk factors for overall morbidity and major morbidity. Results Preoperative comorbidity was recorded in 161 patients (72.5%). Lobectomy (64.9% ) was the predominant surgical procedure. The median number of dissected LN was 14, with the range of 0 to 57. The overall morbidity was 63.5% , including major morbidity of 13.5%. Perioperative mortality was 1.8% (4 cases). The results of binary logistic regression analyses indicated that the independent risk factors for overall morbidity were preoperative weight loss (P =0.020), ASA score (P＜0.001), MVV (% predicted) (P=0. 020 ) and the number of dissected LN ( P = 0.004 ). The independent risk factors for major morbidity were ASA score ( P =0.003), MVV (% predicted) (P= 0.018) and the location of tumor (P=0.007). Conclusion Preoperative weight loss and numbers of dissected mediastinal lymph nodes were risk factor for lung cancer patients older than 70 years, Proper perioperative management for the elderly patients with high ASA score, low MVV (% predicted) or central tumor, could reduce the major postoperative morbidity.

Risk factors of morbidity after pulmonary resection for lung cancer in patients older than 70 years

Objective This study is to analyse the clinical feature and risk factors of morbidity after pulmonary resection for lung cancer in patients older than 70 years. Methods The clinical records of 222 patients older than 70 years who had undergone pulmonary resection for their lung cancer was reviewed. The patients were divided into 3 groups: group Ⅰ including the patients who had severe postoperative complications, group Ⅱ including the patients who had mild complications and group Ⅲ including the patients who had no complications. Moreover, the definitions were made that group A1 = group Ⅰ+ Ⅱ , group B1 = group Ⅲ, group A2 = group Ⅰ and group B2 = group Ⅱ + Ⅲ. Univariate analyses and multivariate binary logistic regressions relating postoperative morbidity to risk factors were performed between the group Al and Bl, A2 and B2, resulting in the identification of the independent risk factors for overall morbidity and major morbidity. Results Preoperative comorbidity was recorded in 161 patients (72.5%). Lobectomy (64.9% ) was the predominant surgical procedure. The median number of dissected LN was 14, with the range of 0 to 57. The overall morbidity was 63.5% , including major morbidity of 13.5%. Perioperative mortality was 1.8% (4 cases). The results of binary logistic regression analyses indicated that the independent risk factors for overall morbidity were preoperative weight loss (P =0.020), ASA score (P＜0.001), MVV (% predicted) (P=0. 020 ) and the number of dissected LN ( P = 0.004 ). The independent risk factors for major morbidity were ASA score ( P =0.003), MVV (% predicted) (P= 0.018) and the location of tumor (P=0.007). Conclusion Preoperative weight loss and numbers of dissected mediastinal lymph nodes were risk factor for lung cancer patients older than 70 years, Proper perioperative management for the elderly patients with high ASA score, low MVV (% predicted) or central tumor, could reduce the major postoperative morbidity.