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Transplant tourism complicated by life‐threatening New Delhi metallo‐β‐lactamase‐1 infection
Authors:Jenell Stewart  Gretchen Snoeyenbos Newman  Rupali Jain  Andrew Bryan  Heather Berger  Martin Montenovo  Ramasamy Bakthavatsalam  Catherine E Kling  Lena Sibulesky  Sherene Shalhub  Ajit P Limaye  Cynthia E Fisher  Robert M Rakita
Abstract:Transplant tourism, which is the practice of traveling to other countries for transplant, continues to be a major problem worldwide. We describe a patient who traveled to Pakistan and underwent commercial kidney transplant. He developed life‐threatening infections from New Delhi metallo‐β‐lactamase‐1–producing Enterobacter cloacae and Rhizopus oryzae, resulting in a necrotizing kidney allograft infection and subsequent external iliac artery rupture. He survived after a prolonged course of nonstandardized antimicrobial therapy, including a combination of aztreonam and ceftazidime‐avibactam, and aggressive surgical debridement with allograft nephrectomy. The early timing of infection with these unusual organisms localized to the allograft suggests contamination and substandard care at the time of transplant. This case highlights the challenges of caring for these infections and serves as a cautionary tale for the potential complications of commercial transplant tourism.
Keywords:antibiotic: antibacterial  clinical research/practice  complication: infectious  infection and infectious agents ‐ bacterial  infection and infectious agents ‐ fungal  infectious disease  kidney transplantation/nephrology  organ sale/trade  organ transplantation in general
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