Cation-osmotic Haemolysis in Patients with Retinal Vein Occlusion |
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Authors: | I KOZÁK G MATÚŠOVÁ A MIROŠŠAY T JUHÁS |
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Institution: | (1) Department of Ophthalmology, CS;(2) Department of Pharmacology, P. J. Šafárik University School of Medicine, Košice, Slovak Republic, CS |
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Abstract: | The purpose of this work was to use a new technique to assess erythrocyte deformability in patients with retinal vein occlusion.
Erythrocyte microrheology changes were measured by cation-osmotic haemolysis (COH) in healthy donors and in patients with
both central (n= 6) and branch (n= 16) retinal vein occlusion up to 12 months after the occlusion. The patient group consisted of five patients with ischaemic
and 17 with oedematous vein occlusion. The control group consisted of the same number of age-, sex- and risk factor (hypertension)-matched
donors. In patients with retinal vein occlusion, COH was significantly decreased compared to the control group. The decrease
was most marked at low and high concentrations of incubating media where the differences reached high statistical significance
(p<0.01–0.001). In our previous experiments we showed that COH and erythrocyte deformability (ED) are closely related and that
COH reflects basic information about erythrocyte deformability. Thus, decreased COH in patients with retinal vein occlusion
points to reduced ED in comparison with the control group. We, therefore, assume that impairment in ED together with other
microrheological abnormalities contributes to the pathophysiology of changes in patients with retinal vein occlusion. |
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Keywords: | :Cation osmotic haemolysis – Erythrocyte deformability – Ocular microrheology – Retinal vein occlusion |
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