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| 环孢菌素A对HL-60和K562细胞增殖的影响 | |
| 引用本文： | 曾斌贝,孙载阳,陈宝安,邵泽叶,宋萍. 环孢菌素A对HL-60和K562细胞增殖的影响[J]. 现代医学, 2002, 30(2): 86-88 |
| 作者姓名： | 曾斌贝 孙载阳 陈宝安 邵泽叶 宋萍 |
| 作者单位： | 1. 江苏省肿瘤医院,内科,江苏,南京,210009 2. 东南大学,现代医学实验中心,江苏,南京,210009 3. 东南大学附属中大医院,血液科,江苏,南京,210009 4. 东南大学医学院,中心实验室,江苏,南京,210009 |
| 摘 要： | 目的 探讨环孢菌素A对HL-60、K562细胞增殖的影响。方法 应用四甲基偶氮唑蓝比色法（MTT法）观察环孢菌素A对HL-60、K562细胞增殖的抑制率，应用电镜进行凋亡的检测。结果 癌细胞在环孢菌素A作用下，细胞增殖被阻遏，并呈现时间剂量效应关系。同时发现环孢菌素A能诱导HL-60、K562细胞凋亡。结论 环孢菌素A可以通过诱导细胞凋亡而抑制HL-60和K562细胞增殖。 |
| 关 键 词： | 环孢菌素A HL－60细胞株 K562细胞株 细胞增殖 细胞凋亡 影响 |
| 文章编号： | 1001-0912(2002)02-0086-03 |
| 修稿时间： | 2001-10-16 |
Effect of cyclosporin A on the proliferation of HL-60 and K562 cells |
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| ZENG Yun ,SUN Zai yang ,CHENG Bao an ,SHAO Ze ye ,SONG Ping. Effect of cyclosporin A on the proliferation of HL-60 and K562 cells[J]. Modern Medical JOurnal, 2002, 30(2): 86-88 | |
| Authors: | ZENG Yun SUN Zai yang CHENG Bao an SHAO Ze ye SONG Ping |
| Affiliation: | ZENG Yun 1,SUN Zai yang 2,CHENG Bao an 3,SHAO Ze ye 4,SONG Ping 4 |
| Abstract: | Objective To investigate the effects of cyclosporin A on the proliferation of HL?60 and K562 cells.Methods The inhibition rate of cyclosporin A on HL?60 and K562 cells was observed by MTT method.The cell apoptosis was assayed by electron microscopy.Results Cyclosporin A inhibited the proliferation of HL 60 and K562 cells,and it presented a time dose effect relationship.Cyclosporin A could also induce apoptosis of HL 60 and K562 cells.Conclusion Cyclosporin A might exert an antiproliferative effect on HL 60 and K562 cells via induction of apoptosis. |
| Keywords: | cyclosporin A HL?60 cell line K562 cell line cell proliferation apoptosis |
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