Neuroprotective effects of extracellular DJ‐1 on reperfusion injury in SH‐SY5Y cells |
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| Authors: | Frank JS Lee |
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| Institution: | Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada |
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| Abstract: | Using an in vitro model of ischemic stroke we treated differentiated SH‐SY5Y cells to oxygen‐glucose deprivation (OGD) followed by a reperfusion period where normal growth conditions were restored. Cells undergoing OGD exhibited significant cell death as measure by propidium iodide staining. However, cells treated with exogenous extracellular DJ‐1 during reperfusion exhibited significant rescue from OGD‐induced cell death. |
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| Keywords: | OGD hypoxia cell death PARK7 |
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