[18F]Nifene test–retest reproducibility in first‐in‐human imaging of α4β2* nicotinic acetylcholine receptors |
| |
| Authors: | Patrick J. Lao Tobey J. Betthauser Dana L. Tudorascu Todd E. Barnhart Ansel T. Hillmer Charles K. Stone Jogeshwar Mukherjee Bradley T. Christian |
| |
| Affiliation: | 1. Department of Medical Physics, University of Wisconsin‐Madison, Madison, Wisconsin;2. Waisman Laboratory for Brain Imaging and Behavior, Madison, Wisconsin;3. Department of Medicine, Biostatistics, Psychiatry, and Clinical and Translational Science, University of Pittsburgh, Pittsburgh, Pennsylvania;4. Department of Radiology and Biomedical Imaging, and Psychiatry, Yale University, New Haven, Connecticut;5. Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;6. Department of Radiological Sciences, University of California‐Irvine, Irvine, California;7. Department of Psychiatry, University of Wisconsin‐Madison, Madison, Wisconsin |
| |
| Abstract: | The aim of this study was to examine the suitability of [18 F]nifene, a novel α4β2* nicotinic acetylcholine receptor (nAChR) radiotracer, for in vivo brain imaging in a first‐in‐human study. Methods : Eight healthy subjects (4 M,4 F;21–69,44 ± 21 yrs) underwent a [18F]nifene positron emission tomography scan (200 ± 3.7 MBq), and seven underwent a second scan within 58 ± 31 days. Regional estimates of DVR were measured using the multilinear reference tissue model (MRTM2) with the corpus callosum as reference region. DVR reproducibility was evaluated with test–retest variability (TRV) and intraclass correlation coefficient (ICC). Results : The DVR ranged from 1.3 to 2.5 across brain regions with a TRV of 0–7%, and did not demonstrate a systematic difference between test and retest. The ICCs ranged from 0.2 to 0.9. DVR estimates were stable after 40 min. Conclusion : The binding profile and tracer kinetics of [18F]nifene make it a promising α4β2* nAChR radiotracer for scientific research in humans, with reliable DVR test–retest reproducibility. |
| |
| Keywords: | α 4β 2 first‐in‐humans positron emission tomography |
|
|
