Nonopsonic phagocytosis of erythrocytes infected with ring-stage Plasmodium falciparum |
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| Authors: | Ayi Kodjo Patel Samir N Serghides Lena Smith Todd G Kain Kevin C |
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| Affiliation: | Department of Medicine, University of Toronto, Ontario, Canada. |
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| Abstract: | Ring-stage parasitized erythrocytes (RPEs) were demonstrated to interact with effector cells of the innate immune system. With receptor blockade studies and CD36-null macrophages, human and murine macrophages were shown to phagocytose RPEs through the pattern recognition receptor CD36. These in vitro data implicate scavenger receptors in the clearance of RPEs. |
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