| 自身对照法测定头孢氨苄甲氧苄啶胶囊溶出度 |
| |
| 引用本文： | 谢元超,张雷,冷佳蔚,郭娜.自身对照法测定头孢氨苄甲氧苄啶胶囊溶出度[J].齐鲁药事,2009,28(3). |
| |
| 作者姓名： | 谢元超 张雷 冷佳蔚 郭娜 |
| |
| 作者单位： | 1. 山东省药品检验所,山东,济南,250101
2. 济南市药品检验所,山东,济南,250001 |
| |
| 摘 要： | 目的建立头孢氨苄甲氧苄啶胶囊溶出度测定方法。方法分别采用自身对照法与对照品对照法测定头孢氨苄甲氧苄啶胶囊的溶出度。结果头孢氨苄甲氧苄啶胶囊溶出度测定自身对照法在8.6～86μg.mL-1呈线性(r=0.9999,n=6),回收率101.9%,RSD=0.5%;与对照品对照法相比简便易行,同时也能反映样品溶出的真实情况,达到质量控制目的。结论本法稳定、简便、准确、可行。
|
| 关 键 词： | 头孢氨苄甲氧苄啶胶囊 溶出度 溶出度自身对照法 溶出度对照品对照法 |
Determination of dissolution of Cefalexin and Trimethoprim Capsule by self-control method |
| |
| XIE Yuan-chao,ZHANG Lei,LENG Jia-wei,GUO Na.Determination of dissolution of Cefalexin and Trimethoprim Capsule by self-control method[J].qilu pharmaceutical affairs,2009,28(3). |
| |
| Authors: | XIE Yuan-chao ZHANG Lei LENG Jia-wei GUO Na |
| |
| Institution: | XIE Yuan-chao,ZHANG Lei,LENG Jia-wei,GUO Na1 |
| |
| Abstract: | OBJECTIVE To establish the assay method of dissolution test on Cefalexin and Trimethoprim Capsule.METHODSSelf-control method and reference substance contrast method were compared.RESULTSThere is a good linear relationship between the concentration and absorbence.The average recovery is 101.89% and RSD is 0.5%.CONCLUSIONThe result shows that the method is accurate,simple and easy,and can be used for the quality control. |
| |
| Keywords: | Cefalexin and Trimethoprim Capsule dissolution test self-control method reference substance contrast method |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
