| 白三烯受体拮抗剂的作用与临床应用评价 |
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| 引用本文： | 张石革,马国辉.白三烯受体拮抗剂的作用与临床应用评价[J].中国医院用药评价与分析,2003,3(2):75-77. |
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| 作者姓名： | 张石革 马国辉 |
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| 作者单位： | 北京大学北京积水潭医院,北京市,100035 |
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| 摘 要： | 目的 :介绍白三烯受体拮抗剂的作用进展和临床应用的评价。方法 :采用国内、外文献综述方法。结果和结论 :近年来 ,高选择性白三烯受体拮抗剂进展十分迅速 ,通过抑制白三烯合成和白三烯受体而对抗哮喘 ,对白三烯受体的选择性高 ,有良好的耐受性和药代动力学性质 ,成为一类新型、安全和有效的抗炎和平喘药物 ,在防治成人和 12岁以上儿童的长期哮喘上展现了良好的治疗前景
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| 关 键 词： | 哮喘 白三烯 白三烯D4受体拮抗剂 进展 临床评价 |
| 文章编号： | 1672-2124(2003)02-0075-03 |
| 修稿时间： | 2003年2月26日 |
Clinical Evaluation on Effect of the Leukotrienes Receptor Antagonists |
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| ZHANG Shige,MA Guohui.Clinical Evaluation on Effect of the Leukotrienes Receptor Antagonists[J].Evaluation and Analysis of Drug-Use in Hospital of China,2003,3(2):75-77. |
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| Authors: | ZHANG Shige MA Guohui |
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| Abstract: | OBJECTIVE:To summarize the aspect of clinical evaluation and progress on leukotrienes D 4 receptor antigonist.METHODS:To collecte medical literatures in recent years at home and abroad.RESULTS & CONCLUSION:Advance in highly selective leukotrienes D 4 receptor antigonist has been swiftly in recent years,it can fight against asthma by inhibiting the synthesis of leukotrienes or antagonizing leukotrienes receptor.It has higher selectivity to leukotrienes D 4 receptor,good tolerance and characters of pharmacokinetics,becoming a new kind of safe and effective drugs in antiinflammation and antiasthma. Leukotrienes D 4 receptor antagonist now has been playing an important roles in prevention and long-term therapy of asthma for adults and children over 12 years old. |
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| Keywords: | asthma leukotrienes leukotrienes D 4 receptor antagonist progress clinical evaluation |
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