| 利多卡因防治大鼠深二度烧伤创面早期加深的作用 |
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| 引用本文： | 史煜华,李利根,柴家科,孙同柱.利多卡因防治大鼠深二度烧伤创面早期加深的作用[J].军医进修学院学报,2010,31(4):372-374. |
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| 作者姓名： | 史煜华 李利根 柴家科 孙同柱 |
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| 作者单位： | 解放军总医院第304临床部烧伤整形科,全军烧伤研究所,北京,100048 |
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| 摘 要： | 目的探讨利多卡因防治深二度烧伤创面早期加深的作用。方法wistar大鼠背部深二度烧伤,治疗组局部应用利多卡因凝胶,对照组涂抹安慰剂,检测烧伤后创面组织中Na-K-ATP酶、髓过氧化物酶（MPO）活性和琥珀酸脱氢酶（SDH）、丙二醛（MDA）的含量,HE染色及增殖细胞核抗原（PCNA）免疫组化染色显示创面组织坏死程度。结果对照组和治疗组SDH和Na-K-ATP酶活性在伤后24h均达到最低,之后逐渐升高,但远低于正常水平。伤后24h治疗组SDH、Na-K-ATP活性高于对照组（P〈0.05）;对照组MPO酶活性在伤后24h达最高,治疗组在伤后48h达最高,之后两组都降低,但仍高于正常水平,对照组MPO活性最高值高于治疗组（P〈0.05）;对照组和治疗组伤后MDA含量一直升高,伤后72h,对照组高于治疗组（P〈0.05）。HE及PCNA染色显示治疗组早期创面进行性损伤明显延缓且较轻,创面组织增殖活力好于对照组。结论深二度烧伤创面早期局部应用利多卡因可减轻创面加深,其机制可能与抑制白细胞浸润、减轻氧化损伤、改善组织活力等因素有关。
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| 关 键 词： | 烧伤 利多卡因 大鼠 过氧化物酶 Na-K-ATP 琥珀酸脱氢酶 |
Preventive and therapeutic effect of lidocaine on early progressive deep second degree burn wound |
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| SHI Yu-hua,LI Li-gen,CHAI Jia-ke,SUN Tong-zhu.Preventive and therapeutic effect of lidocaine on early progressive deep second degree burn wound[J].Academic Journal of Pla Postgraduate Medical School,2010,31(4):372-374. |
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| Authors: | SHI Yu-hua LI Li-gen CHAI Jia-ke SUN Tong-zhu |
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| Institution: | SHI Yu-hua,LI Li-gen,CHAI Jia-ke,SUN Tong-zhuDepartment of Burn Plastic Surgery,Chinese PLA Burn Institute,304 Clinical Division,Chinese PLA General Hospital,Beijing 100048,China |
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| Abstract: | Objective To study the preventive and therapeutic effect of lidocaine on early progressive deep second degree burn wound. Methods Wistar rats were divided into control group and treatment group. Rats in the treatment group were treated with local lidocaine gel, rats in the control group received placebo. Na+-K+-ATPase and myeloperoxidase(MPO) activity and succinate dehydrogenase(SDH) and malonaldehyde(MDA) level in wound tissue were measured. HE and immunohistochemical staining for proliferating cell nuclea... |
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| Keywords: | Burns Lidocaine Rats Peroxidase Na+-K+-ATPase Succinate Dehydrogenase |
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