急性脑梗死患者血清白介素-6水平与颈动脉斑块的关系探讨

目的 探讨急性脑梗死患者血清白介素-6(Interleukin-6,IL-6)水平的变化与颈动脉斑块的关系.方法 将151例急性脑梗死患者根据颈动脉超声检查分为3个亚组,即无斑块组42例,稳定斑块组53例,不稳定斑块组56例,抽取上述3组患者发病急性期2d和恢复期14d时空腹静脉血,采用双抗体夹心酶联免疫吸附法测定血清IL-6的水平,并与45例健康对照者进行对比.结果 (1)脑梗死急性期2d不稳定斑块组的IL-6水平明显高于稳定斑块组、无斑块组及对照组,稳定斑块组的IL-6水平明显高于无斑块组及对照组,无斑块组的IL-6水平明显高于对照组,差异均具有统计学意义(F=57.46,P＜0.05).(2)脑梗死恢复期14 d不稳定斑块组的IL-6水平明显高于稳定斑块、无斑块组及对照组,稳定斑块组的IL-6水平明显高于无斑块组及对照组,差异均有统计学意义(F=46.31,P＜0.05),无斑块组与对照组差异无统计学意义(P＞0.05).结论 急性脑梗死患者血清IL-6的水平与斑块形成以及斑块的稳定性密切相关.

Relationship between carotid artery plaque and serum interleukin-6 level in patients with acute cerebral infarction

Objective To explore the relationship between carotid artery plaque and serum interleukin-6 level in patients with acute cerebral infarction.Methods Totally 151 patients with acute cerebral infarction were divided into three subgroups by using carotid ultra-sonographic methods,no carotid plaques group(n=42),stable plaque group(n=53),and vulnerable plaques group(n=56).Forty-five healthy people were selected as control group.Serum IL-6 was measured by enzyme linked immunosorbent assay(ELISA) in the second day and the fourteenth day.Results In the second day of infarction,the IL-6 level of vulnerable plaques group was significantly higher than that in stable plaque group,no carotid plaques group and control group,IL-6 level of stable plaque group was significantly higher than that in no carotid plaques group and control group,and IL-6 level of no carotid plaques group was significantly higher than that in control group,the differences were statistically significant(F=57.46,P<0.05).In the fourteenth day of infarction,IL-6 level of vulnerable plaques group was significantly higher than that in stable plaque group,no carotid plaques group and control group,and IL-6 level of stable plaque group was significantly higher than that in no carotid plaques group and control group,the differences were statistically significant(F=46.31,P<0.05).There was no significant difference between no carotid plaques group and control group(P>0.05).Conclusion The level of serum IL-6 in patients with acute cerebral infarction is closely related with plaque formation and plaque stability.