多发性硬化患者认知改变与事件相关电位研究

目的研究多发性硬化(MS)患者认知功能障碍的发生情况,及其与事件相关电位(ERPs)的相关关系。方法对70例MS患者进行韦氏智力量表测查及ERPs检查。结果韦氏智力量表测试发现MS组全量表智商(FIQ)不正常者(<90分)的比率为40%(28/70),与正常组比较差异显著(P<0.01)。MS组N2、P300潜伏期明显延长,与对照组比较差异具有显著性(P<0.05)。脑或脑脊髓型及进展型MS患者P300潜伏期明显延长,P300波幅降低。病程与P300潜伏期呈显著正相关。言语量表智商(VIQ)、FIQ与P300潜伏期呈负相关,与P300波幅呈正相关;操作量表智商(PIQ)与P300波幅呈正相关。结论MS患者存在有认知障碍。ERPs检查对MS认知障碍的判断有一定参考意义。

A study of cognitive function with event-related potentials in multiple sclerosis

Objective To investigate the occurrence of cognitive function disorders of multiple sclerosis(MS),as well as the correlations between cognitive dysfunction and the event-related potentials(ERPs).Methods 70 patients with MS were tested with the Wechsler Intelligence Scale and ERPs.Results The rate of the patients whose full intelligence quotient(FIQ) was less than 90 scores was 40%(28/70),which was higher than that of the normal group(P<0.01).The latency of N2,P300 of ERPs was significantly longer in MS than that of in the normal control group(P<0.05).The amplitude of P300 was also lower in the patients whose lesions in the brain or in the patients who belong to the progressive type.The positive correlation between P3 latency and the disease duration was significant,as well as the positive correlation between P3 amplitude and IQ.The negative correlation between P3 latency and verbal intelligence quotient(VIQ) and FIQ was also significant respectively.Conclusion Cognitive impairment was a common occurrence in MS.The P300 examination is a valuble target for appraising cognitive state in MS.