氟伐他汀联合贝那普利对慢性充血性心力衰竭患者血清pro-BNP、CRP水平和心功能的影响

目的观察氟伐他汀联合贝那普利治疗慢性充血性心力衰竭的疗效。方法 84例慢性充血性心力衰竭患者随机分为治疗组和对照组。对照组给予贝那普利及常规治疗,治疗组在此基础上加用氟伐他汀,疗程1年。观察心功能(HF)情况、B型脑钠肽前体(pro-BNP)、C反应蛋白(CRP)水平。结果 1年后,与对照组相比,治疗组HF改善优于对照组(P<0.05),血清中pro-BNP、CRP水平下降(P<0.05)。结论氟伐他汀联合贝那普利治疗慢性充血性心力衰竭效果优于单用贝那普利。

Affection of combined treatment with fluvastatin and benazepril on pro-BNP, CRP level and. heart function of chronic congestive heart failure patients

Objective To observe the affection of combined treatment with fluvastatin and benazepri on heart function（HF） and pro-BNP, CRP level of chronic congestive heart failure （CCHF） patients. Methods Eighty-four cases were divided into therapy group and control group. The control group was treated with benazepril and therapy group was treated with fluvastatin based on control group for I year as a course. Pro-BNP,CRP level,HF and echocardiography indictors were detected. Results 1 year later,compared with control group,HF in therapy group was improved （P 〈 0.05）. The level of pro-BNP, CRP in therapy group was lower（P 〈 0.05 ）. Conclusion The combination therapy with fluvastatin and benazepri is better than single use of benazepri.