建立中医药网络心血管病学的思考

随着复杂网络理论研究的进展，对于复杂系统的认识和探索方法已经发生了革命性的变化。基于网络的方法应用在生物医学研究中，产生了网络生物学和网络药理学。心血管系统可以抽象为一个复杂网络，而心血管疾病则可以看作网络结构和功能的损伤所致。中医药治疗心血管疾病确有良好的临床疗效，而其相关机制至今仍未阐明。笔者提出在复杂网络理论、网络生物学和网络药理学指导下，应用网络的方法来研究中医药防治心血管疾病的机制，从而产生一门新的学科——中医药网络心血管病学。本文简单介绍了复杂网络理论、网络生物学和网络药理学，从网络的角度阐发了“病-证-方-药”相关的实质。将网络生物学用于分析心血管疾病和证候，网络药理学用于分析复方和中药，这种基于“网络一网络”的研究方法可以为阐明中医药机制提供新的视角。

Thinking on building the network cardiovasology of Chinese medicine

With advances in complex network theory, the thinking and methods regarding complex systems have changed revolutionarily. Network biology and network pharmacology were built by applying network-based approaches in biomedical research. The cardiovascular system may be regarded as a complex network, and cardiovascular diseases may be taken as the damage of structure and function of the cardiovascular network. Although Chinese medicine （CM） is effective in treating cardiovascular diseases, its mechanisms are still unclear. With the guidance of complex network theory, network biology and network pharmacology, networkbased approaches could be used in the study of CM in preventing and treating cardiovascular diseases. A new discipline -- network cardiovasology of CM was, therefore, developed. In this paper, complex network theory, network biology and network pharmacology were introduced and the connotation of ＂disease-syndrome-formula-herb＂ was illustrated from the network angle. Network biology could be used to analyze cardiovascular diseases and syndromes and network pharmacology could be used to analyze CM formulas and herbs. The ＂network-network＂-based approaches could provide a new view for elucidating the mechanisms of CM treatment.