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Corpus Callosum Morphometrics in Young Children with Autism Spectrum Disorder |
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| Authors: | Inbal Boger-Megiddo Dennis W W Shaw Seth D Friedman Bobbi F Sparks Alan A Artru Jay N Giedd Geraldine Dawson Stephen R Dager |
| Institution: | (1) Department of Radiology, 5C-1, Children’s Hospital & Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA;(2) Cancer Epidemiology Research Coop, Public Health Sciences, Seattle, WA, USA;(3) Department of Radiology, University of Washington School of Medicine, Seattle , WA, USA;(4) Department of Anesthesiology, University of Washington School of Medicine, Seattle , WA, USA;(5) National Institute of Mental Health, Bethesda, MD, USA;(6) Department of Psychology, Center on Human Development & Disability, University of Washington, Seattle, WA, USA |
| Abstract: | This study assessed midsagittal corpus callosum cross sectional areas in 3–4 year olds with autism spectrum disorder (ASD) compared to typically developing (TD) and developmentally delayed (DD) children. Though not different in absolute size compared to TD, ASD callosums were disproportionately small adjusted for increased ASD cerebral volume. ASD clinical subgroup analysis revealed greater proportional callosum reduction in the more severely affected autistic disorder (AD) than in pervasive developmental disorder-not otherwise specified (PDD-NOS) children. DD children had smaller absolute callosums than ASD and TD. Subregion analysis revealed widely distributed callosum differences between ASD and TD children. Results could reflect decreased inter-hemispheric connectivity or cerebral enlargement due to increase in tissues less represented in the corpus callosum in ASD. |
| Keywords: | MRI Autism Brain structure Corpus callosum |
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