| 具抗癌活性的鬼桕毒电子自旋标记物的生物学作用研究——Ⅱ.对环腺苷酸磷酸二酯酶的影响 |
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| 引用本文： | 张尔贤,俞丽君,沈立光.具抗癌活性的鬼桕毒电子自旋标记物的生物学作用研究——Ⅱ.对环腺苷酸磷酸二酯酶的影响[J].中国生化药物杂志,1993(3). |
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| 作者姓名： | 张尔贤 俞丽君 沈立光 |
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| 作者单位： | 汕头大学生物学系，汕头大学生物学系，汕头大学生物学系 |
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| 摘 要： | 本文观察了鬼桕毒自旋标记衍生物对家兔脑环腺苷酸磷酸二酯酶活性的抑制作用,结果表明,化合物对该酶的活性有较强的抑制作用,抑制率接近阳性对照药物—氨茶碱的作用,达30～40％。
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| 关 键 词： | 自旋标记物 鬼桕毒 抗癌活性 环腺苷酸磷酸二酯酶 活性 |
Study on Biological Function of Spin-Labeled Anticancer Podophyllotoxin Derivatives——Ⅱ . The Inhibition on the Activity of Cyclic Adenosine 3' , 5'-Monophosphate Phosphodiestease |
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| Zhang Erxian,Yu Tijun Shen ligueng.Study on Biological Function of Spin-Labeled Anticancer Podophyllotoxin Derivatives——Ⅱ . The Inhibition on the Activity of Cyclic Adenosine 3' , 5'-Monophosphate Phosphodiestease[J].Chinese Journal of Biochemical Pharmaceutics,1993(3). |
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| Authors: | Zhang Erxian Yu Tijun Shen ligueng |
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| Institution: | Zhang Erxian,Yu Tijun Shen ligueng
Department of Biology,Shantou University |
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| Abstract: | Investigation has been made of the inhibiting effect of spin labeled compounds of podophyllo-toxin on the activity of cAMP-PDE extracted from rabbit brain. On the whole, the inhibiting rates of podophyllotoxin reaches 30~40%, which is similar to that of the positive drug-theophylline. |
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| Keywords: | Spin labeled derivative Podophyllotoxin Anticancer activity Cyclic adenosine 3' 5' -monophosphate phosphodiestease (cAMP-PDE) Activity |
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