| 千金藤立定与镇痛药的协同作用 |
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| 引用本文： | 段世明,卞春甫,余逸民,马振明. 千金藤立定与镇痛药的协同作用[J]. 徐州医学院学报, 1985, 0(4) |
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| 作者姓名： | 段世明 卞春甫 余逸民 马振明 |
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| 作者单位： | 徐州医学院药理学教研室(段世明，卞春甫，余逸民)，徐州医学院药理学教研室(马振明) |
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| 摘 要： | 用小鼠热板法测痛,应用1—SPD(20mg/kg.ip)后,于10,20min时能显著地提高痛阈(P<0.01)。1—SPD分别与度冷丁或双氢埃托菲合用,ip后10min时痛阈提高率分别大于二药单用痛阈提高率之和,镇痛时间也明显延长。结果提示:1—SPD能加强镇痛药的镇痛作用。
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| 关 键 词： | 镇痛 左旋千金藤立定 度冷丁 双氢埃托菲 |
Synergism between 1-spo and Analgesics |
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| Duan Shiming,et al. Synergism between 1-spo and Analgesics[J]. Acta Academiae Medicinae Xuzhou, 1985, 0(4) |
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| Authors: | Duan Shiming et al |
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| Affiliation: | Duan Shiming,et al Department of Pharmacology,Xuzhou Medical College,Jiangsu |
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| Abstract: | In mice, intraperitoneal l-stepholidine( 1-SPD 20mg/kg),dolantin ( 15mg/kg ) and dihydroetorphine ( DHE 2ug/kg ) raised pain threshold ( hot-plate method) by 175%, 163% and 90%,respectively ( p<0.01 ). The combined uses of 1-SPD with dolantin or of 1-SPD with DHE elevated pain threshold by 369% and 433% respecively ( P<0.01 ) , and the duration of analgesia was prolonged markedly as compared with the drugs used alone. The results revealed that there is synergism between 1-SPD and either dolantin or DHE. |
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| Keywords: | analgesia 1-stepholidine dolantin dihydroetorphine |
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