| 丹参酮ⅡA磺酸钠注射液对糖尿病大鼠肾脏的保护作用 |
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| 引用本文： | 周儒兵,刘明华,何海霞. 丹参酮ⅡA磺酸钠注射液对糖尿病大鼠肾脏的保护作用[J]. 中国药业, 2008, 17(13): 7-8 |
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| 作者姓名： | 周儒兵 刘明华 何海霞 |
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| 作者单位： | [1]重庆市肿瘤研究所,重庆400030; [2]第三军医大学西南医院急救部,重庆400038; [3]重庆医科大学附属第一医院临床药理系·基础医学院生物工程研究所,重庆400016 |
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| 摘 要： | 目的探讨丹参酮ⅡA磺酸钠注射液对糖尿病大鼠肾脏损害的保护作用及其机制。方法将36只大鼠随机分为对照组、糖尿病组和丹参酮ⅡA磺酸钠注射液治疗组（治疗组），后两组制备2型糖尿病大鼠模型。采用免疫组化技术与流式细胞技术检测肾小管上皮细胞转分化过程中的标志蛋白[α-平滑肌肌动蛋白（α—SMA）、波形蛋白（vimentin）及转化生长因子-β1（TGF-β1）]在肾小管上皮细胞中的表达。结果治疗组α-SMA，vimentin及TGF-β1表达均较糖尿病组下调。结论丹参酮ⅡA磺酸钠注射液能延缓糖尿病大鼠的肾间质纤维化。
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| 关 键 词： | 糖尿病 糖尿病肾病 肾小管 丹参酮ⅡA磺酸钠注射液 |
Protective Effect of Sulfotanshinone Sodium Injection on Diabetic Rat Kidney |
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| Zhou Rubin,Liu Minghua,He Haixia. Protective Effect of Sulfotanshinone Sodium Injection on Diabetic Rat Kidney[J]. China Pharmaceuticals, 2008, 17(13): 7-8 |
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| Authors: | Zhou Rubin Liu Minghua He Haixia |
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| Affiliation: | Zhou Rubin, Liu Minghua, He Haixia( 1. Chongqing Cancer Hospital, Chongqing, China 400030; 2. Department of Emergency, Southwest Hospital, Third Military Medical University, Chongqing, China 400038; 3. Biotechnological Research Institute, Preclinical Medical College, Department of Clinical Pharmacology, the First Affiliated Hospital, Chongqing Medical University, Chongqing, China 400016) |
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| Abstract: | Objective To study the renal protective effect and mechanism of sulfotanshinone sodium injection on diabetic rat kidney, Methods Thirty-six rats were divided into control group,diabetic group and sulfotanshinone sodium injection treatment group. Type-2 diabetes mellitus （DM） rat models were established. Immunohistochemical staining and flow cytometry were used to detect the expressions of α-SMA, vimentin, TGF- β1 in renal tubular epithelial cells. Results The expressions of α- SMA, vimentin and TGF-β1 decreased more obviously in the sulfotanshinone sodium injection treatment group than diabetic group, Conclusion Sulfotanshinone sodium injection can delay the interstitial fibrosis in diabetic nephropathy rats. |
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| Keywords: | diabetes mellitus diabetic nephropathy kidney tubules sulfotanshinone sodium injection |
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