| 动物麻醉机在肠易激综合征模型大鼠评价中的应用 |
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| 引用本文： | 蔡琴燕,唐影,黄杨,祝福存,林春.动物麻醉机在肠易激综合征模型大鼠评价中的应用[J].福建医科大学学报,2011,45(1):29-33. |
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| 作者姓名： | 蔡琴燕 唐影 黄杨 祝福存 林春 |
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| 作者单位： | 福建医科大学,基础医学院神经生物学研究中心疼痛研究室,福州,350004 |
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| 基金项目： | 福建省自然科学基金，福建教育厅科学基金，福建医科大学教授基金 |
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| 摘 要： | 目的 探索动物麻醉机在腹外斜肌放电测量中的应用,为肠易激综合征(IBS)模型内脏痛敏的评价提供一种更为客观、有效的方法.方法 对新生期SD大鼠给予结直肠扩张刺激,建立成年大鼠IBS模型.分别在清醒和浅麻醉状态下测量腹外斜肌对结直肠扩张的放电反应来评价大鼠内脏痛觉的敏感性.结果 在清醒和浅麻醉两种状态下,IBS模型组大鼠...
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| 关 键 词： | 肠易激综合征 内脏 疼痛 麻醉 大鼠 Sprague-Dawley 动作电位 腹肌 疾病模型 动物 |
Application of Animal Anesthesia Machine to Assessment of Rat Model of Irritable Bowel Syndrome |
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| CAI Qinyan,TANG Ying,HUANG Yang,ZHU Fucun,LIN Chun.Application of Animal Anesthesia Machine to Assessment of Rat Model of Irritable Bowel Syndrome[J].Journal of Fujian Medical University,2011,45(1):29-33. |
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| Authors: | CAI Qinyan TANG Ying HUANG Yang ZHU Fucun LIN Chun |
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| Institution: | CAI Qinyan,TANG Ying,HUANG Yang,ZHU Fucun,LIN Chun Laboratory of Pain Research,Department of Neurobiochemistry,College of Pre-clinical Medicine,Fujian Medical University,Fuzhou 350004,China |
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| Abstract: | Objective To explore the application of animal anesthesia machine to measuring spikes of external oblique abdominal muscle in rats in order to establish a more objective and effective method for the assessment of the visceral sensitivity in the model of irritable bowel syndrome(IBS).Methods IBS rat models received colorectal irritation in neonates.Responses of external oblique abdominal muscle to colorectal distension in the conscious and slight anesthetic condition were measured to assess the visceral sens... |
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| Keywords: | Irritable Bowel Syndrome Viscera Pain Anesthesia Rats Sprague-Dawley Action Potentials Abdominal Muscles Disease Models Animal |
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