| 建立小鼠子宫内膜损伤模型的研究 |
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| 引用本文： | 曲军英,吕一帆,林茵,江一平. 建立小鼠子宫内膜损伤模型的研究[J]. 福建医科大学学报, 2011, 45(1): 34-36,44 |
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| 作者姓名： | 曲军英 吕一帆 林茵 江一平 |
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| 作者单位： | 曲军英,QU Junying(福建医科大学附属第一医院,妇产科,福州,350005);吕一帆,林茵,LV Yifan,LIN yin(福建医科大学,福州,350004);江一平,JIANG Yiping(福建医科大学细胞发育与组织工程研究室,福州,350004) |
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| 摘 要： | 目的 建立小鼠子宫内膜损伤模型.方法 借鉴热球子宫内膜去除术原理,利用宫腔导管贯穿小鼠Y型宫腔的一侧,给予预温85 ℃流动热水经80 s热损伤小鼠子宫内膜组织,达到子宫内膜广泛剥脱目的.结果 处理后48 h宫腔内见子宫内膜层广泛脱落,部分子宫腔壁内膜完全脱落,内膜间质可见大量血管充血;处理后7 d子宫腔及浅肌层大量的炎...
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| 关 键 词： | 子宫内膜 疾病模型,动物 高温,诱发 |
Mouse Model Endometrial Injury |
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| QU Junying,LV Yifan,LIN yin,JIANG Yiping. Mouse Model Endometrial Injury[J]. Journal of Fujian Medical University, 2011, 45(1): 34-36,44 |
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| Authors: | QU Junying LV Yifan LIN yin JIANG Yiping |
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| Affiliation: | QU Junying1,LV Yifan2,LIN yin2,JIANG Yiping3 1.Department of Obstetrics and Genecology,The Affiliated First Hospital,Fujian Medicine University,Fuzhou 350005,China,2.2007 Classes Master Graduate Student,The First Clinical College of Fujian Medicine University,Fuzhou 350004,3.Center of Cell Developmental and Biology |
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| Abstract: | Objective Established mice endometrial damage model.Methods Reference the principle of thermal balloon endometrial ablation,use of intrauterine catheter through the right side of mice y-shape uterine cavity,give advance temperature 85 ℃ flow hot water by 80 s heat damage mice endometrial organization.Results Treatment after 48 h,uterine cavity see endometrial layer falls off,part uterine cavity wall lining fall off completely,endometrial interstitial visible abundant vascular congestion,after processing 7 d uterine cavity and shallow muscularis lots of inflammatory cells infiltration,did not see the obvious glandular structures,the processed uterine cavity form 14 d to narrow or atresia,did not see the normal endometrium,and inflammatory cells infiltrating and fibrosis performance,uterine shape it still exists.Co-cage,damage did not affect mice embryos conceived,but can still exist in not damaged side uterine cavity.Conclusion The animal model of endometrial damaged can be established by thermal damage. |
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| Keywords: | Endometrium Disease Models Animal Hyperthermia Induced |
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