| 关节腔内注射三氧化二砷治疗胶原诱导的大鼠关节炎的初步观察 |
| |
| 引用本文： | 刘红,高锦团,李拾林.关节腔内注射三氧化二砷治疗胶原诱导的大鼠关节炎的初步观察[J].福建医科大学学报,2011,45(2):93-96. |
| |
| 作者姓名： | 刘红 高锦团 李拾林 |
| |
| 作者单位： | 刘红,高锦团,LIU Hong,GAO Jintuan(福建医科大学附属第二医院免疫内科,泉州,362000);李拾林,LI Shilin(福建医科大学附属第二医院超声科,泉州,362000) |
| |
| 摘 要： | 目的 探讨关节腔内注射三氧化二砷(ATO)治疗胶原诱导的关节炎(CIA)的可行性及疗效.方法 成年雌性Wistar大鼠建立CIA动物模型.将成功造模的大鼠分成对照组和治疗组,分别于踝关节腔内注射PBS溶液和10% ATO溶液各0.1 mL,每3 d 1次,共4次,末次注射3 d后取材.2组分别于注射前及注射后进行关节炎...
|
| 关 键 词： | 关节炎 类风湿 滑膜 疾病模型 动物 砷剂 氧化物 大鼠 Wistar |
Preliminary Examination of Intra-articular Injection Arsenic Trioxide for Treatment of Collagen-induced Arthritis in Rats |
| |
| LIU Hong,GAO Jintuan,LI Shilin.Preliminary Examination of Intra-articular Injection Arsenic Trioxide for Treatment of Collagen-induced Arthritis in Rats[J].Journal of Fujian Medical University,2011,45(2):93-96. |
| |
| Authors: | LIU Hong GAO Jintuan LI Shilin |
| |
| Institution: | LIU Hong1,GAO Jintuan1,LI Shilin21.Department of Immunology,2.Department of Ultrasound,The Affiliated Second Hosptital,Fujian Medical University,Quanzhou 362000,China |
| |
| Abstract: | Objective To investigate the feasibility and effectiveness of intra-articular arsenic trioxide injection for treatment of rat collagen-induced arthritis.Methods Adult female Wistar rats were used to induce CIA and the rats were divided into two groups:control group and treat group.Their ankle joints were injected with 0.1 mL PBS and 10% arsenic trioxide respectively,once every three days,a total of four times.Then they were killed three days after the last injection.The treated ankles were assessed included... |
| |
| Keywords: | arthritis rheumatoid synovial membrane disease models animal arsenicals oxides rats wistar |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
