Analysis of factors associated with successful allogeneic peripheral blood stem cell collection in healthy donors |
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| Affiliation: | 1. Department of Laboratory Medicine, National Cancer Center, Goyang, South Korea;2. Center for Hematologic Malignancy, National Cancer Center, Goyang, South Korea;1. Department of Internal Medicine, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil;2. Bone Marrow Transplantation Unit, Hospital das Clínicas, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil;1. Department of Internal Medicine, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil;2. Bone Marrow Transplantation Unit, Hospital das Clínicas, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil;1. Department of Internal Medicine, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil;2. Bone Marrow Transplantation Unit, Hospital das Clínicas, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil;1. Center for Cell-based Therapy and Regional Blood Center, Ribeirão Preto, Brazil;2. Department of Internal Medicine, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil;1. Department of Internal Medicine, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil;2. Bone Marrow Transplantation Unit, Hospital das Clínicas, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil;1. Division of Pediatric Hematology and Oncology, The Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Ramat Gan, Israel;2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;3. Ella Institute of Immuno-Oncology, Sheba Medical Center, Ramat Gan, Israel;1. University of Lyon, Faculty of Medicine of Saint-Etienne, Saint-Etienne, France;2. Institut National de la Transfusion Sanguine, Paris, France;1. Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. The Michener Institute of Education at University Health Network, Toronto, Canada;1. Department of Transfusion Medicine, Institute of Liver and Biliary Sciences, New Delhi, 110 070, India;2. Department of Pathology, Institute of Liver and Biliary Sciences, New Delhi, 110 070, India;3. Department of Liver Transplant Surgery, Institute of Liver and Biliary Sciences, New Delhi 110 070, India |
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| Abstract: | BackgroundThe collection of a sufficient number of stem cells is important for success of allogeneic hematopoietic stem cell transplantation (HSCT). This study aimed to investigate the factors associated with successful allogeneic peripheral stem cell (PBSC) collection in healthy donors.MethodsWe retrospectively reviewed clinical data of allogeneic PBSC collection in 175 donors from 2007 to 2017 at the National Cancer Center, Korea. This study analyzed factors associated with the CD34+ cell yield such as the characteristics of donors, including age, laboratory results before apheresis, and data of procedures on the first day. The CD34+ cell dose of ≥ 4.0 × 106/kg have recently been the accepted minimum recommended dose in allogeneic HSCT settings, and this was the target dose in our study.ResultsThe factors associated with the CD34+ cell yield were age (p = 0.007), baseline platelet (PLT) (p = 0.014), and pre-collection hematopoietic progenitor cells (HPCs) (p = 0.001) by multivariate analysis. This study represented that age, baseline platelet count, and pre-collection HPC count are important predictive factors as shown in other previous studies.ConclusionOur data suggest that young age, high baseline platelet counts and high HPC counts before collection might be useful for identifying successful mobilizers. |
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| Keywords: | Allogeneic Peripheral blood stem cells Apheresis |
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