Comparison of efficacy of packed red blood cell transfusion based on its hemoglobin content versus the standard transfusion practice in thalassemia major patients (HEMOCON study) |
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| Affiliation: | 1. Department of Transfusion Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India;2. Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India;1. Pediatric Hematology Specialist, University of Health Sciences, Dr Sami Ulus Children’s Hospital, Ankara, Turkey;2. the Pediatric Hematology Unit of the Department of Pediatrics, Medical School of Gazi University, Ankara, Turkey;3. the Pediatric Hematology Unit of the Department of Pediatrics, Medical School of Süleyman Demirel University, Isparta, Turkey;4. the Pediatric Hematology Unit of the Department of Pediatrics, Medical School of Kırıkkale University, Kırıkkale, Turkey;5. Medical School of Gazi University, Ankara, Turkey;6. the Pediatric Hematology Unit of the Department of Pediatrics, Medical School of Başkent University, Ankara, Turkey;7. Pediatric Hematology Specialist, Ankara Dışkapı Child Health and Diseases Hematology Oncology Training And Research Hospital, Ankara, Turkey;1. International Consultancy in Strategic Advice on Safety Improvements of Blood-Derived Bioproducts and Suppliers Quality Audit / Inspection, London, UK;2. Romagna Transplant Network, Hematology Unit, Ravenna-I, Italy;1. SH/Scientific-Hemostasis, Scientific Director and Consultant in Hemostasis and Thrombosis Diagnostics, Franconville, France;2. Hyphen BioMed, Neuville sur Oise, France;3. International Consultancy in Strategic Safety Improvements of Blood-Derived Bioproducts and Suppliers Quality Audit / Inspection, London, UK;1. Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece;2. Department of Biology, Section of Cell Biology and Biophysics, School of Science, National and Kapodistrian University of Athens, Greece;1. Stem Cell Mobilization and Collection Unit, Italy;2. PICC Team, IEO IRCCS, Milano, Italy;1. Department of Hematology, Fukushima Medical University, Fukushima, Japan;2. Department of Blood Transfusion and Transplantation Immunology,Fukushima Medical University, Fukushima, Japan;3. Department ofPediatric Oncology, Fukushima Medical University Hospital, Fukushima, Japan |
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| Abstract: | The hemoglobin (Hb) content of packed red blood cell (PRBC) units is heterogenous. The efficacy of a transfusion episode can be assessed if the Hb content of the PRBC is known and the patient’s post-transfusion Hb increment is also determined. This prospective study compared the efficacy of PRBC transfusion based on its Hb content versus the standard transfusion practice. A total of 160 thalassemia major patients were enrolled and randomly divided into two equal groups: Group I (n = 80) – they received ABO/RhD identical PRBCs after determining its Hb content (≥50 g); and Group II (n = 80) – they received randomly selected ABO/RhD identical PRBCs. Hb estimation and a direct antiglobulin test were performed on the post-transfusion sample (1 h). The mean Hb content of the PRBC units was significantly higher (p = 0.000) in group I (67.86 ± 8.07 g; range: 50.80–92.13 g) than group II (60.92 ± 8.29 g; range: 40.86–86.76 g). The mean Hb increment was also significantly higher in group I patients (p = 0.04). In both the groups, there was a significant negative correlation between Hb increment and weight, age, body surface area and blood volume (p < 0.05). There was a significant positive correlation between Hb increment and Hb dose adjusted for body surface area as well as blood volume (p < 0.05). PRBC transfusion was more efficacious in patients who were transfused with PRBCs having a Hb content ≥50 g as compared to those who received randomly selected PRBCs. |
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| Keywords: | Packed red blood cell Hemoglobin content Thalassemia major |
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