Safety and immunogenicity of the tetravalent,live-attenuated dengue vaccine Butantan-DV in adults in Brazil: a two-step,double-blind,randomised placebo-controlled phase 2 trial |
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| Affiliation: | 1. Department of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, São Paulo, Brazil;2. Department of Pediatrics, School of Medicine, University of São Paulo, São Paulo, Brazil;3. Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, Brazil;4. Division of Clinical Trials and Pharmacovigilance, Instituto Butantan, São Paulo, Brazil;5. Preventive Medicine Department, Federal University of São Paulo, São Paulo, Brazil;6. Instituto Adolfo Lutz, São Paulo, Brazil;7. Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, San Diego, CA, USA;8. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA;9. Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;1. Global Clinical Science, Sanofi Pasteur, Marcy l''Etoile, France;2. Translational Sciences and Biomarkers, Sanofi Pasteur, Marcy l''Etoile, France;3. Global Clinical Immunology, Sanofi Pasteur, Swiftwater, PA, USA;4. Translational Sciences and Biomarkers, Sanofi Pasteur, Swiftwater, PA, USA;5. Sanofi, Beijing, China;6. Central Virology Laboratory, Public Health Services, Israel Ministry of Health, Chaim Sheba Medical Center, Ramat Gan, Israel;7. Institute of Tropical Medicine, Chaim Sheba Medical Center & Sackler Faculty of Medicine, Tel-Aviv University, Israel;8. Research and Development Department, Sanofi Pasteur, Lyon, France;1. Sanofi Pasteur, Swiftwater, PA, USA;2. Sanofi Pasteur, Marcy L’Étoile, France;3. Sanofi Pasteur, Montevideo, Uruguay;4. Sanofi Pasteur, Singapore, Singapore;1. Sanofi Pasteur, Santa Catarina, Coyoacán, Mexico City, Mexico;2. Sanofi Pasteur, Singapore;3. Centro de Estudios en Infectología Pediátrica, Universidad del Valle and Centro Médico Imbanaco, Cali, Valle del Cauca, Colombia;4. Research Institute for Tropical Medicine, Filinvest Corporate City, Alabang, Muntinlupa, Metro Manila, Philippines;5. Clinica de la Costa, Barranquilla, Atlántico, Colombia;6. Manila Doctors Hospital, Ermita, Metro Manila, Philippines;7. Infectious Diseases, Internal Medicine, Hospital Pablo Tobón Uribe, Universidad de Antioquia, Medellín, Antioquia, Colombia;8. University of the Philippines Manila—Philippine General Hospital, Ermita, Metro Manila, Philippines;9. Sanofi Pasteur, Swiftwater, PA, USA;10. Sanofi Pasteur, Marcy L''Etoile, France;11. Sanofi Pasteur, Montevideo, Uruguay;12. Sanofi Pasteur, Chaoyang, Beijing, China;13. Sanofi Pasteur, Bogotá, Colombia;14. Sanofi Pasteur, Taguig, Metro Manila, Philippines;1. Hospital del Niño Dr José Renán Esquivel, Panama City, Panama;2. Sistema Nacional de Investigación, SENACYT, Panama City, Panama;3. Takeda Vaccines, Singapore, Singapore;4. De La Salle Health Sciences Institute, Cavite, Philippines;5. Hospital Universitario Maternidad Nuestra Señora de la Altagracia, Santo Domingo, Dominican Republic;6. Centro de Vacunación Internacional S A (Cevaxin), Panama City, Panama;7. Takeda Pharmaceuticals International, Zurich, Switzerland;8. Takeda Pharmaceuticals, Rio de Janeiro, Brazil;1. Schneider Institutes for Health Policy, Heller School for Social Policy and Management, Brandeis University, Waltham, MA, USA;2. Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA;1. Sanofi Pasteur, Mexico City, Mexico;2. Sanofi Pasteur, Singapore;3. Centro de Estudios en Infectologia Pediatrica, Universidad del Valle and Clinica Imbanaco, Cali, Valle del Cauca, Colombia;4. Research Institute for Tropical Medicine Muntinlupa, Philippines;5. Clinica de la Costa, Barranquilla, Colombia;6. Manila Doctors Hospital, Manila, Philippines;7. Department of Infectious Diseases and Department of Internal Medicine, Hospital Pablo Tobón Uribe, Universidad de Antioquia, Medellin, Colombia;8. University of the Philippines Manila–Philippine General Hospital, Manila, Philippines;9. Sanofi Pasteur, Montevideo, Uruguay;10. Sanofi Pasteur, Swiftwater, PA, USA;11. Sanofi Pasteur, Beijing, China;12. Sanofi Pasteur, Bogota, Colombia;13. Sanofi Pasteur, Taguig, Philippines |
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