Umbilical cord blood: Current uses for transfusion and regenerative medicine |
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| Institution: | 1. The Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, North Carolina;2. Division of Pediatric Blood and Marrow Transplant, Duke University Medical Center, Durham, North Carolina;3. Division of Pediatric Hematology-Oncology, Lucille Packard Children''s Hospital, Stanford University, Palo Alto, California;4. Division of Hematologic Malignancies and Cellular Therapy, Duke Cancer Institute, Duke University, Durham, North Carolina;5. Department of Pathology, Duke University Medical Center, Durham, North Carolina;6. Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina;7. Division of Pediatric Infectious Diseases, Ann & Robert H. Lurie Children''s Hospital of Chicago, Chicago, Illinois;1. Department of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada;2. Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;3. Library Services, The Ottawa Hospital, Ottawa, Ontario, Canada;1. Department of Hematology and Oncology, Beijing Huairou Hospital, Beijing, China;2. Department of Hematology and Oncology, Laoshan Branch of No. 401 Hospital of Chinese People''s Liberation Army (PLA), Qingdao, China;3. Department of Hematology, Chinese PLA General Hospital, Beijing, China |
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| Abstract: | The past 20 years of experience with umbilical cord blood transplantation have demonstrated that cord blood is effective in the treatment of a spectrum of diseases, including hematological malignancies, bone marrow failure, hemoglobinopathies, and inborn errors of metabolism. However, only a few number of umbilical cord blood units collected have a cell content adequate for an allogenic hematopoietic stem cell transplantation. In the meanwhile, there is an increasing interest in exploiting cord blood derivatives in different fields. In this review, we will summarize the most recent updates on clinical applications of umbilical cord blood platelet derivatives for regenerative medicine, and we will revise the literature concerning the use of umbilical cord blood for autologous or allogeneic transfusion purposes. The methodological aspect and the biological characteristics of these products also will be discussed. |
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| Keywords: | Umbilical cord blood platelet gel Umbilical cord blood serum Umbilical cord blood transfusion Allogenic cord RBC |
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