A caerulein-sensitive potentiation of the behavioral effects of apomorphine by dibutyryl-cAMP |
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| Authors: | Everett H. Ellinwood W.J.Kenneth Rockwell Nancy Wagoner |
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| Affiliation: | Behavioral Neuropharmacology Section, Department of Psychiatry, Duke University Medical Center PO Box 3870, Durham, NC 27710, USA |
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| Abstract: | The dopaminergic behavioral effects of apomorphine in rats were evaluated using a rating scale. Caerulein, a decapeptide physiologically similar to cholecystokinin, enhanced at lower doses and inhibited at higher doses the behaviors induced by apomorphine. Dibutyryl-cAMP, but not dibutyryl-cGMP, potentiated apomorphine behaviors. The potentiation was inhibited by a high dose of caerulein. These data provide evidence for an opposing effect of cAMP and caerulein or cholecystokinin in modulating dopaminergic systems. |
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| Keywords: | Caerulein Cholecystokinin Apomorphine Dopamine Dibutyryl-cAMP Dibutyryl-cGMP Gastric peptides Rats |
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