Migraine and cluster headache – the common link |
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| Authors: | Anne?Luise?Vollesen Silvia?Benemei Francesca?Cortese Alejandro?Labastida-Ramírez Francesca?Marchese Lanfranco?Pellesi Michele?Romoli Messoud?Ashina Christian?Lampl |
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| Affiliation: | 1.Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences,University of Copenhagen,Copenhagen,Denmark;2.Health Sciences Department,University of Florence and Headache Centre, Careggi University Hospital,Florence,Italy;3.Department of Medico-Surgical Sciences and Biotechnologies, Sapienza,University of Rome,Latina,Italy;4.Dep Internal Medicine, Division of Vascular Pharmacology, Erasmus Medical Center,Rotterdam,The Netherlands;5.Child Neuropsichiatry Unit,University of Palermo,Palermo,Italy;6.Medical Toxicology, Headache and Drug Abuse Center,University of Modena and Reggio Emilia,Modena,Italy;7.Neurology Clinic,University of Perugia - S.M. Misericordiae Hospital,Perugia,Italy;8.Department of Neurogeriatric Medicine, Headache Medical Center Linz,Ordensklinikum Linz Barmherzige Schwestern,Linz,Austria |
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| Abstract: | Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients. |
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