A comparison of the effects of corticotropin releasing factor and sauvagine on food intake

Corticotropin releasing factor (CRF) and sauvagine (SVG) when administered ICV both reduced spontaneous feeding as well as feeding induced by deprivation or the administration of ethylketocyclazocine (EKC). For spontaneous- and EKC-induced feeding, SVG produced a larger and longer-lasting suppressive effect than did CRF. Both peptides produced a conditioned taste aversion when paired with a novel saccharin taste. As with the feeding effects, SVG produced a stronger aversion than CRF. These studies further establish the similarity between CRF and SVG and suggest that they may have a disruptive effect on feeding.