Quantitative prediction of tumor response to neoadjuvant chemotherapy in breast cancer: novel marker genes and prediction model using the expression levels |
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| Authors: | Hiroshi Sano Satoru Wada Hidetaka Eguchi Akihiko Osaki Toshiaki Saeki Masahiko Nishiyama |
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| Affiliation: | (1) Department of Breast Oncology, International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka Saitama, 350-1298, Japan;(2) Research Institute for Development Therapeutics, Saitama Medical University, 1397-1 Yamane, Hidaka Saitama, 350-1298, Japan; |
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| Abstract: | Background In breast cancer, the identification of accurate predictors of tumor response to neoadjuvant chemotherapy is of key importance, but none of the critical markers have been validated to date. We attempted to identify potent marker genes genome-wide, and we developed a prediction model for individual response to epirubicin (EPI)/cyclophosphamide (CPM) combination chemotherapy (EC). |
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