| 重组人粒细胞巨噬细胞集落刺激因子凝胶剂治疗溃疡药效学研究 |
| |
| 引用本文： | 王忠,杨宝峰. 重组人粒细胞巨噬细胞集落刺激因子凝胶剂治疗溃疡药效学研究[J]. 西北药学杂志, 2007, 22(5): 254-255 |
| |
| 作者姓名： | 王忠 杨宝峰 |
| |
| 作者单位： | 1. 哈药集团生物工程有限公司,黑龙江,哈尔滨,150020
2. 哈尔滨医科大学药理教研室,黑龙江,哈尔滨,150086 |
| |
| 摘 要： | 目的观察重组人粒细胞巨噬细胞集落刺激因子(gm-csf)凝胶剂治疗溃疡的药效。方法在豚鼠背部造溃疡模型,将凝胶剂外涂于豚鼠背部的溃疡处,不同时间内考察gm-csf凝胶剂对溃疡的药效。结果gm-csf凝胶剂组及gm-csf原液组同盐水组、基质组比较,溃疡面积明显缩小,有显著差异。结论gm-csf凝胶剂对溃疡有明显的治疗作用。
|
| 关 键 词： | 重组人粒细胞巨噬细胞集落刺激因子凝胶剂 溃疡 药效学 |
| 文章编号： | 1004-2407（2007）05-0254-02 |
| 收稿时间： | 2006-12-06 |
| 修稿时间： | 2006-12-06 |
Study on the pharmacodynamics of recombinant human granulocyte macrophage colony stimulating factor gel in ucler therapy |
| |
| WANG Zhong,YANG Bao-feng. Study on the pharmacodynamics of recombinant human granulocyte macrophage colony stimulating factor gel in ucler therapy[J]. Northwest Pharmaceutical Journal, 2007, 22(5): 254-255 |
| |
| Authors: | WANG Zhong YANG Bao-feng |
| |
| Affiliation: | 1. Harbin Pharmaceutical Group Bioproduct Co. , LTD. Heilongjiang Harbin 150020 ;2. Department of Pharmacology, Harbin Medicine University, Heilongjiang , Harbin 150086 |
| |
| Abstract: | Objective To observe the pharmacodynamics of recombinant human granulocyte macrophage-colony stimulating factor gel in ucler therapy.Methods Ucler model was made on guinea back,gm-csf gel was smeared on the place of guinea back ucler,and the therapy effect of gm-csf gel for ucler was observed.Results Gm-csf gel group and gm-csf solution were compared with NaCl solution and ground substence gel.The area of guinea ucler was definitely reduced;experiments group shows significant difference when compared with control groups.Conclusion The results demonstrate gm-csf gel having evident therapy function for ulcer. |
| |
| Keywords: | recombinant human granulocyte macrophage-colony stimulating factor gel ulcer pharmacodynamics |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
