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Keratin‐18 and microRNA‐122 complement alanine aminotransferase as novel safety biomarkers for drug‐induced liver injury in two human cohorts
Authors:Petra Thulin  Gunnar Nordahl  Marcus Gry  Getnet Yimer  Eleni Aklillu  Eyasu Makonnen  Getachew Aderaye  Lars Lindquist  C Mikael Mattsson  Björn Ekblom  Daniel J Antoine  B Kevin Park  Stig Linder  Alison H Harrill  Paul B Watkins  Björn Glinghammar  Ina Schuppe‐Koistinen
Institution:1. AstraZeneca R&D, Innovative Medicines Personalised Healthcare & Biomarkers, Science for Life Laboratory, , Solna, Sweden;2. Former AstraZeneca R&D, Global Safety Assessment, Molecular Toxicology, , S?dert?lje, Sweden;3. Department of Pharmacology, Faculty of Medicine, Addis Ababa University, , Addis Ababa, Ethiopia;4. Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, , Huddinge, Sweden;5. Department of Internal Medicine, Faculty of Medicine, Addis Ababa University, , Addis Ababa, Ethiopia;6. Department of Medicine, Division of Infectious Diseases, Karolinska Institutet, Karolinska University Hospital, , Huddinge, Sweden;7. ?strand Laboratory of Work Physiology, Swedish School of Sport and Health Sciences, Karolinska Institutet, , Stockholm, Sweden;8. MRC Centre for Drug Safety Science, Department of Molecular & Clinical Pharmacology, University of Liverpool, , Liverpool, UK;9. Department of Oncology‐Pathology, Karolinska Institutet, Karolinska University Hospital, , Solna, Sweden;10. School of Pharmacy, University of North Carolina at Chapel Hill, , Chapel Hill, NC, USA;11. AstraZeneca R&D, Drug Safety & Metabolism, , M?lndal, Sweden
Abstract:
Keywords:acetaminophen  biomarkers  drug development  hepatotoxicity     HIV     liver  plasma  safety  toxicology  tuberculosis
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